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Data showing how Repeated Lumbar Punctures within 3 days may affect CSF Biomarker Levels

SND-ID: snd1132-1. Version: 2. DOI: https://doi.org/10.5878/14p1-3w07

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Citation

Creator/Principal investigator(s)

Martin Olsson - University of Gothenburg orcid

Johan Ärlig - University of Gothenburg

Jan Hedner - University of Gothenburg, the Institute of Medicine

Kaj Blennow - University of Gothenburg, Institute of Neuroscience and Physiology

Henrik Zetterberg - University of Gothenburg, Institute of Neuroscience and Physiology

Research principal

University of Gothenburg - Institute of Neuroscience and Physiology rorId

Description

As an extension of a study on the relationship between sleep deprivation and cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease, we performed two Lumbar punctures (LPs) within three days in 13 healthy volunteers (N=13). Our aim was to investigate CSF biomarker dynamics in relation to sleep deprivation. An unexpected sharp rise in biomarker concentrations in the second sample made us consider an artifact and we therefore repeated the experiment, but without sleep restriction, in four additional individuals (N=4). A similar rise in biomarker levels were evident, suggesting an inherent methodological problem with repeated LPs.

Experiment 1: Repeated lumbar punctures within 3 days without sleep intervention.
Participants with controled normal sleep. Biomarker concentrations from each individual lumbar puncture.

Experiment 2: After sleep deprivation and 3 days later, after recovery sleep.
Biomarker concentrations from each individual lumbar puncture. First puncture immediately after sleep deprivation. Second puncture three days later, after recovery sleep.

Data contains personal data

No

Language

Method and outcome

Unit of analysis

Population

Healthy volunteers

Study design

Cross-over

Description of study design

Randomized crossover

Sampling procedure

Other
13 healthy volunteers recruited by posters on university campus. 20-40 years of age with no sleep disturbances. Body-Mass-index (BMI) < 30 kg/m2. No continual use of medication or relevant chronic diseases. Self-reported normal bedtime < 00.00, regular morning awakening hours 06.00-09.00, habitual sleep duration of between 6.5-8.5 hours and absence of sleep disturbances (such as chronic insomnia/daytime sleepiness/narcolepsy). Epworth Sleepiness Scale (ESS) score < 11.

Experiment then repeated with 4 additional individuals

Time period(s) investigated

2015-02-01 – 2016-02-29

Biobank is connected to the study

Yes

Variables

8

Number of individuals/objects

17

Data format / data structure

Data collection
Geographic coverage
Administrative information

Responsible department/unit

Institute of Neuroscience and Physiology

Ethics Review

Gothenburg - Ref. 823-14

Topic and keywords

Research area

Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)

Keywords

Cerebrospinal fluid, Cerebrospinal fluid proteins, Amyloid beta-peptides, Lumbar puncture, Tau, Cerebrospinal fluid proteins, Csf

Publications

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Olsson M, Arlig J, Hedner J, Blennow K, Zetterberg H. Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer's disease. Sleep. 2018;41(5). https://doi.org/10.1093/sleep/zsy025
Link to article
DOI: https://doi.org/10.1093/sleep/zsy025

Olsson, M., Ärlig, J., Hedner, J. et al. Repeated lumbar punctures within 3 days may affect CSF biomarker levels. Fluids Barriers CNS 16, 37 (2019) doi:10.1186/s12987-019-0157-2
Link to article
DOI: https://doi.org/10.1186/s12987-019-0157-2

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Versions

Version 2. 2024-08-08

Version 2: 2024-08-08

DOI: https://doi.org/10.5878/14p1-3w07

Data merged: Data from: " Repeated lumbar punctures within 3 days may affect CSF biomarker levels - Repeated lumbar punctures within 3 days without sleep intervention" (version 1.0, DOI 10.5878/tpbk-k885); " Repeated lumbar punctures within 3 days may affect CSF biomarker levels - Repeated lumbar punctures. After sleep deprivation and 3 days later, after recovery sleep" (version 1.0, DOI 10.5878/cavp-eh78).

Version 1.0. 2019-11-29

Version 1.0: 2019-11-29

DOI: https://doi.org/10.5878/tpbk-k885

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Published: 2024-08-08