Uppsala Family Study

SND-ID: ext0175-1.

Is part of collection at SND: Swedish Cohort Consortium (Cohorts.se)

Access to data via

Contact

Liisa Byberg

liisa.byberg@surgsci.uu.se

Creator/Principal investigator(s)

Liisa Byberg - Uppsala University, Department of Surgical Sciences

Research principal

Uppsala University - Department of Surgical Sciences

Description

The Uppsala Family Study was initiated in 2000-2001 when 602 families (mothers, fathers, two consecutive siblings age 5-14 years) living in Uppsala were examined with focus on anthropometry and blood pressure. Blood samples were taken for biochemical and genetic analyses. Parents answered medical and lifestyle questionnaires and filled in a medical questionnaire for each child. Families were randomly selected from a sampling frame where children were selected from the Medical Birth Registry based on them being consecutive singleton full siblings where both had high or low birth weight or where they were discordant in birth weight. In 2010-2014, all families were invited for a second round of examinations; 513 parents (age 39-70 years) and 466 children (age 14-23 years) attended. This second round of examinations included largely the same procedures as the first round; anthropometry, blood pressure, blood sampling, and all participants answered a detailed questionnaire on medical history, lifestyle habits including physical activity, education and living conditions. Additionally, participants underwent DXA-scans to determine bone, fat and lean muscle mass. Additional information available includes pregnancy specific information from the Medical Birth Registry (children), parental birth data and longitudinal information on children's growth from child and school health records. The family design of the Uppsala Family Study provides good opportunities to examine the contribution of maternal and paternal factors on, for instance, the association between birth weight and later outcomes in the offspring.

Purpose:

To study effects of birth weight and growth on cardiovascular, metabolic and bone-related outcomes using a family design. Show less..

Method and outcome

Unit of analysis

Individual

Time Method

Longitudinal: Cohort/Event-based

Sampling procedure

Probability

Data format / data structure

Numeric

Data collection

Data collection 1

Mode of collection: Physical measurements and tests
Time period(s) for data collection: 2000 – 2001
Source of the data: Population group, Biological samples

Data collection 2

Mode of collection: Self-administered questionnaire
Time period(s) for data collection: 2000 – 2001
Source of the data: Population group, Biological samples

Data collection 3

Mode of collection: Self-administered questionnaire
Time period(s) for data collection: 2010 – 2014
Source of the data: Population group, Biological samples

Data collection 1

Mode of collection: Physical measurements and tests
Time period(s) for data collection: 2000 – 2001
Source of the data: Population group, Biological samples

Data collection 2

Mode of collection: Self-administered questionnaire
Time period(s) for data collection: 2000 – 2001
Source of the data: Population group, Biological samples

Data collection 3

Mode of collection: Self-administered questionnaire
Time period(s) for data collection: 2010 – 2014
Source of the data: Population group, Biological samples

Data collection 4

Mode of collection: Physical measurements and tests
Time period(s) for data collection: 2010 – 2014
Source of the data: Population group, Biological samples

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Geographic coverage

Administrative information

Responsible department/unit

Department of Surgical Sciences

Topic and keywords

Research area

Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)

Health (CESSDA Topic Classification)

Keywords

Anthropometry, Blood pressure, Life style, Health status, Education, Birth weight, Growth, Lifestyle factors, Blood sample, National register, Swedish cohort consortium (scc), Cohorts.se

Publications

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Leon DA, Koupil I, Mann V, Tuvemo T, Lindmark G, Mohsen R, Byberg L, Lithell H. Fetal, developmental, and parental influences on childhood systolic blood pressure in 600 sib pairs: the Uppsala Family Study. Circulation 2005;112(22):3478-85. doi: 10.1161/CIRCULATIONAHA.104.497610

Khanolkar AR, Byberg L, Koupil I. Parental influences on cardiovascular risk factors in Swedish children aged 5-14 years. Eur J Public Health 2012;22(6):840-7. doi: 10.1093/eurpub/ckr180

Nitsch D, Sandling JK, Byberg L, Larsson A, Tuvemo T, Syvänen AC, Koupil I, Leon DA. Fetal, developmental and parental influences on cystatin C in childhood: the Uppsala Family Study. Am J Kidney Dis 2011;57(6):863-72. doi: 10.1053/j.ajkd.2010.12.025

Weedon MN, Frayling TM, Shields B, Knight B, Turner T, Metcalf BS, Voss L, Wilkin TJ, McCarthy A, Ben-Shlomo Y, Davey Smith G, Ring S, Jones R, Golding J, Byberg L, Mann V, Axelsson T, Syvänen AC, Leon D, Hattersley AT. Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. Diabetes 2005;54(2):576-81. doi: 10.2337/diabetes.54.2.576

Silverwook RJ, De Stavola BL, Cole TJ, Leon DA. BMI peak in infancy as a predictor for later BMI in the Uppsala Family Study. Int J Obes 2009;33(8):929-37. doi: 10.1038/ijo.2009.108

Mann V, De Stavola BL, Leon DA. Separating within and between effects in family studies: an application to the study of blood pressure in children. Stat Med 2004; 23(17):2745-56.

Koupil I. The Uppsala studies on developmental origins of health and disease. J Intern Med 2007;261(5):426-36.

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