Coffee, homocysteine and B vitamins
SND-ID: snd0015-1.
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Contact
Elisabeth Strandhagen
Associated documentation
Creator/Principal investigator(s)
Dag Thelle
Elisabeth Strandhagen - University of Gothenburg, Department of Public Health and Community Medicine
Henrik Zetterberg - University of Gothenburg, Institute of Neuroscience and Physiology
Research principal
University of Gothenburg
- Department of Public Health and Community Medicine
Description
Elevated level of homocysteine has been identified as a graded and independent risk factor for coronary heart disease. The metabolism of homocysteine is dependent on the availability of the B-vitamins, folate, vitamin B12, and vitamin B6 (pyridoxal phosphate). Although elevated levels of tHcy in plasma and serum is particularly seen in folate deficiency, elevated levels are also seen in the presence of folate levels in the lower reference range. The study was organised as a prospective, cross-over, blinded controlled trial with the participants randomly allocated to two different groups which will consume:
1) For 3 weeks: Both groups: no coffee
2) For 4 weeks: Group A: 4 cups of coffee/day + placebo, Group B: 4 cups of coffee/day + 200 g folate/day
1) For 3 weeks: Both groups: no coffee
2) For 4 weeks: Group A: 4 cups of coffee/day + placebo, Group B: 4 cups of coffee/day + 200 g folate/day
3) For 3 weeks: Both groups: no coffee (wash out)
4) For 4 weeks: Group A. 4 cups of coffee/day + 40 g B-6/day, Group B: 4 cups of coffee/day + placebo.
The participants were randomised again in the beginning of the second part. Each participant met at five visits. They were allowed to drink other beverages. Diet habits were registered during the study. Blood samples were drawn and blood pressure measured at every visit. Blood samples were analysed for homocysteine in plasma and total cholesterol, HDL-cholesterol, triglycerides, Lp(a), folate, ALAT, ASAT, urate and gamma-GT in serum. Frosen whole blood is available.
Purpose:
To investigate the interaction of coffee consumption on the effects of folate and vitamin B-6 on the methionin metabolism and thereby on the plasma homocysteine levels. Show less..
Data contains personal data
No
Language
Unit of analysis
Population
The participants were in the age-range 35-69 years and usual coffee drinkers, free of clinically recognised chronic diseases such as cardiovascular diseases, cancer, renal disorders, liver disease, diabetes mellitus, and were not on anti-epileptic or chol
Study design
Experimental study
Sampling procedure
Time period(s) investigated
2000-10 – 2001-04
Variables
93
Number of individuals/objects
121
Data format / data structure
Responsible department/unit
Department of Public Health and Community Medicine
Research area
Cardiac and cardiovascular systems (Standard för svensk indelning av forskningsämnen 2011)
Nutrition and dietetics (Standard för svensk indelning av forskningsämnen 2011)
Health (CESSDA Topic Classification)
Specific diseases, disorders and medical conditions (CESSDA Topic Classification)
Keywords
Blood pressure, Blood specimen collection, Homocysteine, Alanine transaminase, Aspartate aminotransferases, Folic acid, Gamma-glutamyltransferase, Genes, Cardiovascular diseases, Coffee, Cholesterol, Dietary supplements, Body height, Body weight, Nutritional sciences, Placebos, Smoking, Triglycerides, Uric acid, Vitamin b complex
Strandhagen E. Coffee and gene interaction. The effect on methionine and lipid metabolism. Thesis, University of Gothenburg, 2004.
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ISBN:
91-628-6022-4
Strandhagen E, Landaas S, Thelle DS. Folate supplement eliminates the homocysteine increasing effect of filtered coffee. A randomised placebo controlled trial. Eur J Clin Nutr, 2003; 57: 1411-1417
Strandhagen E, Thelle DS. Filtered coffee raises serum cholesterol. Results from a controlled intervention trial. Eur J Clin Nutr, 2003; 57: 1164-1168.
Strandhagen E, Zetterberg H, Aires N, Palmér M, Rymo L, Blennow K, Landaas S, Thelle DS. The methylenetetrahydrofolate reductase C677T polymorphism is a major determinant of coffee-induced increase of plasma homocysteine: a randomized placebo controlled study. Int J Mol Med 2004: 6: 811-5.
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Strandhagen E, Zetterberg H, Aires A, Palmér M, Rymo L, Blennow K, Thelle DS. The apolipoprotein E genetic polymorphism and the cholesterol raising effect of coffee. Lipids in Health and Disease 2004; 3: 26 (30Nov2004)
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