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The Environmental Determinants of Diabetes in the Young - TEDDY: follow up study

SND-ID: ext0080-2.

Is part of collection at SND: Scania Metadatabase for Epidemiology (SME)

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Creator/Principal investigator(s)

Åke Lernmark - Lunds universitet, Institutionen för kliniska vetenskaper, avdelningen för diabetes och endokrinologi

Research principal

Lund University - Institutionen för kliniska vetenskaper, avdelningen för diabetes och endokrinologi rorId

Description

Umbilical cord blood was taken from 48000 new born children in the county of Skåne in order to determine the risk of hereditary type 1 diabetes. Of the screened children 7,4% had an increased risk. Of these, 2,525 children participate in the study follow-up part. TEDDY children will be followed until they are 15 years old. Up until 4 years of age, the child visits a TEDDY office every 3 months. After 4 years of age, the visits takes place two times per year. If the child shows signs of an autoimmune process started, that the child has acquired antibodies in the blood, the child are followed-up every three months in the future. The study includes blood, feaces, urine and saliva samples as well as samples from the nails. Height and weight are recorded and children's physical activity is measured. Food Diary conducted during periods and sample on the family's tap water is taken. Further interviews are conducted and the parents respond to different questionnaires.

Purpose:

To identify environmental exposures that are associated with increased risk of developing autoantibodies against pancreati

... Show more..
Umbilical cord blood was taken from 48000 new born children in the county of Skåne in order to determine the risk of hereditary type 1 diabetes. Of the screened children 7,4% had an increased risk. Of these, 2,525 children participate in the study follow-up part. TEDDY children will be followed until they are 15 years old. Up until 4 years of age, the child visits a TEDDY office every 3 months. After 4 years of age, the visits takes place two times per year. If the child shows signs of an autoimmune process started, that the child has acquired antibodies in the blood, the child are followed-up every three months in the future. The study includes blood, feaces, urine and saliva samples as well as samples from the nails. Height and weight are recorded and children's physical activity is measured. Food Diary conducted during periods and sample on the family's tap water is taken. Further interviews are conducted and the parents respond to different questionnaires.

Purpose:

To identify environmental exposures that are associated with increased risk of developing autoantibodies against pancreatic islet beta cells in children. Children who develop two or more islet cell autoantibodies develop type 1 diabetes, which may take months or years. The secondary aim is to study the mechanisms behind why some children that developed two or more islet cell autoantibodies eventually develop diabetes. Show less..
Method and outcome

Unit of analysis

Time period(s) investigated

2004-09 – Ongoing

Number of individuals/objects

2525

Data format / data structure

Data collection
Geographic coverage

Geographic spread

Geographic description: Scania (5 additional centres in USA,Finland and Germany)

Administrative information

Responsible department/unit

Institutionen för kliniska vetenskaper, avdelningen för diabetes och endokrinologi

Topic and keywords

Research area

Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)

Clinical medicine (Standard för svensk indelning av forskningsämnen 2011)

Endocrinology and diabetes (Standard för svensk indelning av forskningsämnen 2011)

Health (CESSDA Topic Classification)

Keywords

Children, Insulin, Diabetes mellitus, type 1, Ambient exposure, Scania, Epihealth, Gad65, Ia-2, Znt8, Viral infections, Epihealth_skåne

Publications

Publication list
Publication list

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