The cohort of 60-year-old men and women

SND-ID: ext0038-1.

Is part of collection at SND: Swedish Cohort Consortium (Cohorts.se)

Access to data via

Contact

Ulf de Faire

ulf.defaire@ki.se

Associated documentation

Questionnaire Cohort of 60yearold men and women.pdf (1.43 MB)

Creator/Principal investigator(s)

Ulf de Faire - Karolinska Institutet, Institute of Environmental Medicine

Research principal

Karolinska Institutet - Institute of Environmental Medicine

Description

The cohort of 60-year old men and women consists of every third man and woman residing in Stockholm county, who during one year (1997 01 07 - 1998 0630) reached the age of 60, and who subsequently was invited to a careful health control, including blood sampling, and completion of a questionnaire, etc (response rate 78 %). Blood samples and DNA were stored in -80 ?C freezers (4 freezers) both at Karolinska Hospital and the Karolinska Institutet. DNA has been extracted on all subjects and 4232 individuals participated at the health check-up. The predictive role of different risk exposures/biomarkers for cardiovascular diseases (CVD) is assessed through annual matching against available national registers. So far 408 incident CVD cases have been registered (up to 2010, on average 12 years of follow up). About 35 international original articles have been generated from the database. Analyses of baseline data indicate that a variety of metabolic disturbances go unrecognized in this age group, many of which are attributed to low levels of physical exercise and bad life-style habits. Through analyses of incident CVD events using nested case-control designs two novel biomarkers have been identified; 1) Anti-PC (phosphorylcholine) a natural IgM antibody of which low levels reflect disturbed immunological defense mechanisms of the vascular wall and 2) CD 93 of which low levels are related to an increased risk for CVD. Novel potential pathways for CVD are currently investigated through determinations of miRNAs in a nested sample of incident myocardial infarctions and controls through collaboration with the University of Milan, Italy. The running of genome-wide analyses (GWAs) is planned. In addition, particular emphasis will be put on evaluating novel inflammatory biomarkers (immunological antibodies like Ox Cardiolipin, PCSK9 etc.) by multiplex techniques such as the Meso Scale platform.

Purpose:

To assess the predictive role of different risk exposures/biomarkers for cardiovascular diseases (CVD). Show less..

Method and outcome

Unit of analysis

Individual

Population

2193 women and 2039 men, living in Stockholm county and 60 years of age when included.

Sampling procedure

Probability: Simple random

Annual match to national registers to obtain information about death and inpatient occasions for cardiovascular diseases

Time period(s) investigated

1997-01-07 – 1998-06-30

Number of individuals/objects

4232

Response rate/participation rate

78%

Data format / data structure

Numeric

Data collection

Data collection 1

Mode of collection: Physical measurements and tests
Time period(s) for data collection: 1997-01-07 – 1998-06-30
Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples, Registers/Records/Accounts

Data collection 2

Mode of collection: Self-administered questionnaire: paper
Time period(s) for data collection: 1997-01-07 – 1998-06-30
Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples, Registers/Records/Accounts

Geographic coverage

Administrative information

Responsible department/unit

Institute of Environmental Medicine

Funding

Funding agency: Swedish Research Council
Funding agency's reference number: 2007-7429

Topic and keywords

Research area

Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)

Cardiac and cardiovascular systems (Standard för svensk indelning av forskningsämnen 2011)

Health (CESSDA Topic Classification)

Keywords

Aged, Physical examination, Blood specimen collection, Life style, Exercise, Socioeconomic factors, Drug therapy, Risk factors, Diet, Medical history taking, Workplace, Biomarkers, Dna, Family, Leisure activities, Pregnancy, Cardiovascular diseases, Health, Body weight, Menstruation, Environmental exposure, Personality, Smoking, Self concept, Social support, Stress, psychological, Heredity, Swedish cohort consortium (scc), Scc, Cohorts.se

Publications

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Rosell MS, Hellénius ML, de Faire UH, Johansson GK. "Associations between diet and the metabolic syndrome vary with the validity of dietary intake data." , Am J Clin Nutr, 2003;78:84-90

de Faire U, Su J, Hua X, Frostegård A, Halldin M, Hellenius ML, Wikström M, Dahlbom I, Grönlund H, Frostegård J. Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism. J Autoimmun. 2010 Mar;34(2):73-9.

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