Supplementary information for dissertation "CAR-T cells for Immunotherapy of Cancer"
SND-ID: 2024-352. Version: 1. DOI: https://doi.org/10.57804/t9yy-1d15
Download all files
Citation
Creator/Principal investigator(s)
Tina Sarén - Uppsala University
Research principal
Description
1. Single-cell RNA analysis reveal subpopulations of CAR T cells correlating with response in lymphoma patients
2. Preclinical evaluation of CAR20(NAP)-T cells for B cell lymphoma
3. Complementary-determining region clustering causes CAR-T cell dysfunction
4. Armed CAR-T cells directed against IL13Rα2 show potent activity against glioblastoma
Differentially expressed genes between responders and non-responders (Fc -1.2 ≤ or ≤ 1.2).
The dataset was originally published in DiVA and moved to SND in 2024.
Data contains personal data
No
Language
Identifiers
Research area
Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)
Keywords
Sarén, T. 2022. CAR T cells for Immunotherapy of Cancer. Digital Comprehensive
Summaries of Uppsala Dissertations from the Faculty of Medicine 1814. 57 pp. Uppsala: Acta
Universitatis Upsaliensis. ISBN 978-91-513-1430-3
ISBN:
978-91-513-1430-3
ISSN:
1651-6206
URN:
urn:nbn:se:uu:diva-468216
Sarén T, Ramachandran M, Gammelgård G, Lövgren T, Mirabello C, Björklund ÅK, Wikström K, Hashemi J, Freyhult E, Ahlström H, Amini RM, Hagberg H, Loskog A, Enblad G, Essand M. Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients. Clin Cancer Res. 2023 Oct 13;29(20):4139-4152. doi: 10.1158/1078-0432.CCR-23-0178. PMID: 37540566; PMCID: PMC10570681.
DOI:
https://doi.org/10.1158/1078-0432.CCR-23-0178
Sarén, T., Saronio, G., Marti Torrell, P. et al. Complementarity-determining region clustering may cause CAR-T cell dysfunction. Nat Commun 14, 4732 (2023). https://doi.org/10.1038/s41467-023-40303-z
DOI:
https://doi.org/10.1038/s41467-023-40303-z
If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.