Supplementary information for dissertation "CAR-T cells for Immunotherapy of Cancer"

SND-ID: 2024-352. Version: 1. DOI: https://doi.org/10.57804/t9yy-1d15

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Citation

Creator/Principal investigator(s)

Tina Sarén - Uppsala University

Research principal

Uppsala University

Description

Supplementary information on the dissertation "CAR T cells for Immunotherapy of Cancer", with the following list of sub-papers:
1. Single-cell RNA analysis reveal subpopulations of CAR T cells correlating with response in lymphoma patients
2. Preclinical evaluation of CAR20(NAP)-T cells for B cell lymphoma
3. Complementary-determining region clustering causes CAR-T cell dysfunction
4. Armed CAR-T cells directed against IL13Rα2 show potent activity against glioblastoma

Differentially expressed genes between responders and non-responders (Fc -1.2 ≤ or ≤ 1.2).

The dataset was originally published in DiVA and moved to SND in 2024.

Data contains personal data

Language

English

Method and outcome

Data format / data structure

Numeric

Text

Data collection

Geographic coverage

Administrative information

Identifiers

URN: urn:nbn:se:uu:diva-468713

URN: urn:nbn:se:uu:diva-468834

URN: urn:nbn:se:uu:diva-468835

URN: urn:nbn:se:uu:diva-468712

Topic and keywords

Research area

Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)

Keywords

Cancer, Clinical trials as topic, Glioblastoma

Publications

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Sarén, T. 2022. CAR T cells for Immunotherapy of Cancer. Digital Comprehensive
Summaries of Uppsala Dissertations from the Faculty of Medicine 1814. 57 pp. Uppsala: Acta
Universitatis Upsaliensis. ISBN 978-91-513-1430-3
ISBN: 978-91-513-1430-3
ISSN: 1651-6206
URN: urn:nbn:se:uu:diva-468216

Sarén T, Ramachandran M, Gammelgård G, Lövgren T, Mirabello C, Björklund ÅK, Wikström K, Hashemi J, Freyhult E, Ahlström H, Amini RM, Hagberg H, Loskog A, Enblad G, Essand M. Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients. Clin Cancer Res. 2023 Oct 13;29(20):4139-4152. doi: 10.1158/1078-0432.CCR-23-0178. PMID: 37540566; PMCID: PMC10570681.
DOI: https://doi.org/10.1158/1078-0432.CCR-23-0178

Sarén, T., Saronio, G., Marti Torrell, P. et al. Complementarity-determining region clustering may cause CAR-T cell dysfunction. Nat Commun 14, 4732 (2023). https://doi.org/10.1038/s41467-023-40303-z
DOI: https://doi.org/10.1038/s41467-023-40303-z

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Published: 2024-06-25