Supplementary information for dissertation "CAR-T cells for Immunotherapy of Cancer"

SND-ID: 2024-352. Version: 1. DOI: https://doi.org/10.57804/t9yy-1d15

Citation

Creator/Principal investigator(s)

Tina Sarén - Uppsala University

Research principal

Uppsala University rorId

Description

Supplementary information on the dissertation "CAR T cells for Immunotherapy of Cancer", with the following list of sub-papers:
1. Single-cell RNA analysis reveal subpopulations of CAR T cells correlating with response in lymphoma patients
2. Preclinical evaluation of CAR20(NAP)-T cells for B cell lymphoma
3. Complementary-determining region clustering causes CAR-T cell dysfunction
4. Armed CAR-T cells directed against IL13Rα2 show potent activity against glioblastoma

Differentially expressed genes between responders and non-responders (Fc -1.2 ≤ or ≤ 1.2).

The dataset was originally published in DiVA and moved to SND in 2024.

Data contains personal data

No

Language

Method and outcome

Data format / data structure

Data collection
Geographic coverage
Topic and keywords

Research area

Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)

Publications

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Sarén, T. 2022. CAR T cells for Immunotherapy of Cancer. Digital Comprehensive
Summaries of Uppsala Dissertations from the Faculty of Medicine 1814. 57 pp. Uppsala: Acta
Universitatis Upsaliensis. ISBN 978-91-513-1430-3
ISBN: 978-91-513-1430-3
ISSN: 1651-6206
URN: urn:nbn:se:uu:diva-468216

Sarén T, Ramachandran M, Gammelgård G, Lövgren T, Mirabello C, Björklund ÅK, Wikström K, Hashemi J, Freyhult E, Ahlström H, Amini RM, Hagberg H, Loskog A, Enblad G, Essand M. Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients. Clin Cancer Res. 2023 Oct 13;29(20):4139-4152. doi: 10.1158/1078-0432.CCR-23-0178. PMID: 37540566; PMCID: PMC10570681.
DOI: https://doi.org/10.1158/1078-0432.CCR-23-0178

Sarén, T., Saronio, G., Marti Torrell, P. et al. Complementarity-determining region clustering may cause CAR-T cell dysfunction. Nat Commun 14, 4732 (2023). https://doi.org/10.1038/s41467-023-40303-z
DOI: https://doi.org/10.1038/s41467-023-40303-z

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Published: 2022-02-28
Last updated: 2024-08-27