Supplementary information for dissertation "CAR-T cells for Immunotherapy of Cancer"

SND-ID: 2024-352. Version: 1. DOI:


Creator/Principal investigator(s)

Tina Sarén - Uppsala University

Research principal

Uppsala University rorId


Supplementary information on the dissertation "CAR T cells for Immunotherapy of Cancer", with the following list of sub-papers:
1. Single-cell RNA analysis reveal subpopulations of CAR T cells correlating with response in lymphoma patients
2. Preclinical evaluation of CAR20(NAP)-T cells for B cell lymphoma
3. Complementary-determining region clustering causes CAR-T cell dysfunction
4. Armed CAR-T cells directed against IL13Rα2 show potent activity against glioblastoma

Differentially expressed genes between responders and non-responders (Fc -1.2 ≤ or ≤ 1.2).

The dataset was originally published in DiVA and moved to SND in 2024.

Data contains personal data



Method and outcome

Data format / data structure

Data collection
Geographic coverage
Topic and keywords

Research area

Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)


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Sarén, T. 2022. CAR T cells for Immunotherapy of Cancer. Digital Comprehensive
Summaries of Uppsala Dissertations from the Faculty of Medicine 1814. 57 pp. Uppsala: Acta
Universitatis Upsaliensis. ISBN 978-91-513-1430-3
ISBN: 978-91-513-1430-3
ISSN: 1651-6206
URN: urn:nbn:se:uu:diva-468216

Sarén T, Ramachandran M, Gammelgård G, Lövgren T, Mirabello C, Björklund ÅK, Wikström K, Hashemi J, Freyhult E, Ahlström H, Amini RM, Hagberg H, Loskog A, Enblad G, Essand M. Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients. Clin Cancer Res. 2023 Oct 13;29(20):4139-4152. doi: 10.1158/1078-0432.CCR-23-0178. PMID: 37540566; PMCID: PMC10570681.

Sarén, T., Saronio, G., Marti Torrell, P. et al. Complementarity-determining region clustering may cause CAR-T cell dysfunction. Nat Commun 14, 4732 (2023).

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Published: 2024-06-25