Functional development in children and youth with cerebral palsy in Uganda
SND-ID: 2021-68-1. Version: 1. DOI: https://doi.org/10.5878/txww-hg72
Citation
Alternative title
Functional development of Ugandan children/youth with CP
Creator/Principal investigator(s)
Angelina Kakooza-Mwesige
- Makerere University Kampala Uganda, Pediatrics and Child Health
Research principal
Karolinska Institutet
- Womens and Children's Health
Description
AIM
To follow the functional development of a population-based cohort of children and youth (C&Y) with cerebral palsy (CP) in rural Uganda and compare their development with developmental trajectories from high-income countries (HIC).
METHODS
Eighty-one C&Y aged 2–17 years with CP were assessed 2015 and 2019 using Gross Motor Function Measure-66 items (GMFM-66), Pediatric Evaluation of Disability Inventory, Ugandan version (PEDI-UG), and functional classification systems. We calculated scaled scores (actual scores) and reference scores (amount of deviation from HIC developmental trajectories). Wilcoxon signed rank test was used for statistical analyses.
RESULTS
C&Y with CP in Uganda exhibited no differences in scaled scores between the first and second assessments for GMFM-66 and PEDI-UG mobility skills, while they exhibited increased PEDI-UG self-care skills (p<0.001). Reference scores were more negative at the second assessment than at the first assessment for GMFM-66 (p=0.002) and PEDI-UG mobility (p=0.036) but not for PEDI-UG self-care. The increased difference in reference scores ove
To follow the functional development of a population-based cohort of children and youth (C&Y) with cerebral palsy (CP) in rural Uganda and compare their development with developmental trajectories from high-income countries (HIC).
METHODS
Eighty-one C&Y aged 2–17 years with CP were assessed 2015 and 2019 using Gross Motor Function Measure-66 items (GMFM-66), Pediatric Evaluation of Disability Inventory, Ugandan version (PEDI-UG), and functional classification systems. We calculated scaled scores (actual scores) and reference scores (amount of deviation from HIC developmental trajectories). Wilcoxon signed rank test was used for statistical analyses.
RESULTS
C&Y with CP in Uganda exhibited no differences in scaled scores between the first and second assessments for GMFM-66 and PEDI-UG mobility skills, while they exhibited increased PEDI-UG self-care skills (p<0.001). Reference scores were more negative at the second assessment than at the first assessment for GMFM-66 (p=0.002) and PEDI-UG mobility (p=0.036) but not for PEDI-UG self-care. The increased difference in reference scores over the 4 years were primarily driven by younger children (2–5 years) and C&Y with milder impairments.
INTERPRETATION
The increased difference in reference scores between assessments suggests that C&Y with CP in Uganda develop motor skills at a lower rate than peers in HIC.
The dataset contains of the following files:
- Functional_development_in Uganda_dataset_Andrews_et_al.csv
- Variable_list_for_functional_development_in_Uganda_dataset_Andrews_et_al.pdf
Information about the tool Gross Motor Function Measure-66 (GMFM-66):
https://www.canchild.ca/en/resources/44-gross-motor-function-measure-gmfm Show less..
Data contains personal data
Yes
Sensitive personal data
Yes
Code key exists
Yes
Language
Unit of analysis
Population
A population-based cohort of children with Cerebral Palsy in a geographically defined area in Eastern Uganda
Study design
Observational study
Sampling procedure
Time period(s) investigated
2015-04 – 2019-12
Variables
35
Number of individuals/objects
81
Geographic spread
Geographic location: Uganda, Sub-Saharan Africa
Geographic description: Iganga/Mayuge Health and Demographic Surveillance Site, Uganda
Responsible department/unit
Womens and Children's Health
Contributor(s)
Makerere University, Pediatrics and Child Health
Funding
-
Funding agency:
Swedish Ressearch council
Ethics Review
Other - Ref. HS1787 & HS2608
Research area
Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)
Neurology (Standard för svensk indelning av forskningsämnen 2011)
Pediatrics (Standard för svensk indelning av forskningsämnen 2011)
Public health, global health, social medicine and epidemiology (Standard för svensk indelning av forskningsämnen 2011)
Physiotherapy (Standard för svensk indelning av forskningsämnen 2011)
Keywords
Kakooza-Mwesige A, Andrews C, Peterson S, Wabwire Mangen F, Eliasson AC, Forssberg H. Prevalence of cerebral palsy in Uganda: a population-based study. Lancet Glob Health. 2017 Dec;5(12):e1275-e1282. doi: 10.1016/S2214-109X(17)30374-1.
DOI:
https://doi.org/10.1016/S2214-109X(17)30374-1
Andrews, C., Namaganda, L., Eliasson, A.-C., Kakooza-Mwesige, A. and Forssberg, H. (2021), Functional development in children with cerebral palsy in Uganda: population-based longitudinal cohort study. Dev Med Child Neurol. https://doi.org/10.1111/dmcn.14996.
DOI:
https://doi.org/10.1111/dmcn.14996
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