A multimodal brain imaging dataset on sleep deprivation in young and old humans: The Sleepy Brain Study 1, version 3

SND-ID: 2020-51-1. Version: 1. DOI: https://doi.org/10.5878/87y5-kh22

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Associated documentation

dataset_description.json (2.84 KB)

README.txt (5.69 KB)

Citation

Creator/Principal investigator(s)

Gustav Nilsonne, KI - Karolinska Institutet, Department of Clinical Neuroscience

Research principal

Karolinska Institutet - Department of Clinical Neuroscience

Description

The Stockholm Sleepy Brain Study I is a functional brain imaging study of 48 younger (20-30 years) and 36 older (65-75 years) healthy participants, with magnetic resonance imaging after normal sleep and partial sleep deprivation in a crossover design. We performed experiments investigating emotional mimicry, empathy for pain, and cognitive reappraisal, as well as resting state functional magnetic resonance imaging (fMRI). We also acquired T1- and T2-weighted structural images and diffusion tensor images (DTI). On the night before imaging, participants were monitored with ambulatory polysomnography and were instructed to sleep either as usual or only three hours. Participants came to the scanner the following evening. Besides MRI scanning, participants underwent behavioral tests and contributed blood samples, which have been stored in a biobank and used for DNA analyses. Participants also completed a variety of self-report measures. The resulting multimodal dataset may be useful for hypothesis generation or independent validation of effects of sleep deprivation and aging, as well as investigation of cross-sectional associations between the different outcomes.
A full description of study design and procedures is available at: https://openarchive.ki.se/xmlui/handle/10616/45181

The dataset is available for download with the tool Datalad (https://www.datalad.org/). The command after installing Datalad is:
datalad install -r https://github.com/NilsonneData/SleepyBrain1.git

Earlier versions of this dataset can be found here: https://openneuro.org/datasets/ds000201/versions/1.0.3 Show less..

Data contains personal data

Language

English

Method and outcome

Unit of analysis

Individual/Patient

Population

Healthy volunteers

Study design

Double-blind randomised trial

Time period(s) investigated

2012-12-04 – 2013-03-27

2013-10-24 – 2014-04-29

Biobank is connected to the study

Yes

Number of individuals/objects

Data format / data structure

Numeric

Text

Other

Data collection

Mode of collection: Measurements and tests
Data collector: Karolinska Institutet
Source of the data: Other

Geographic coverage

Administrative information

Responsible department/unit

Department of Clinical Neuroscience

Contributor(s)

Stockholm University, Stress Research Institute

Funding 1

Funding agency: Riksbankens Jubileumsfond
Funding agency's reference number: P15-0310:1

Funding 2

Funding agency: Fredrik and Ingrid Thuring Foundation
Funding agency's reference number: 2014-00037, 2015-00170

Ethics Review

Stockholm - Ref. 2012/1098-31/2

Topic and keywords

Research area

Neurosciences (Standard för svensk indelning av forskningsämnen 2011)

Keywords

Emotions, Electromyography, Magnetic resonance imaging, Sleep deprivation, Polysomnography, Expressed emotion, Diffusion tensor imaging

Publications

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Åkerstedt T, Lekander M, Nilsonne G, Tamm S, d’Onofrio P, Kecklund G, Fischer H, Schwarz J, Petrovic P, Månsson KNT. Gray matter volume correlates of sleepiness: a voxel–based morphometry study in younger and older adults. Nature and Science of Sleep 2020, 12, 289-198.
DOI: https://doi.org/10.2147/NSS.S240493

Nilsonne G, Tamm S, d’Onofrio P, Thuné HÅ, Schwarz J, Lavebratt C, Liu, JJ, Månsson KNT, Sundelin T, Axelsson J, Fransson P, Kecklund G, Fischer H, Lekander M, Åkerstedt Torbjörn. A multimodal brain imaging dataset on sleep deprivation in young and old humans. Karolinska Open Archive. url: http://hdl.handle.net/10616/45181
Handle: https://hdl.handle.net/10616/45181

Koba C, Notaro G, Tamm S, Nilsonne G, Hasson U. Spontaneous eye-movements during eyes-open rest reduce resting-state-network modularity by increasing visual-sensorimotor connectivity. bioRχiv. doi: 10.1101/2020.05.18.100669
DOI: https://doi.org/10.1101/2020.05.18.100669

Åkerstedt T, Lekander M, Nilsonne G, Tamm S, d’Onofrio P, Kecklund G, Fischer H, Schwarz J. Effects of late night short sleep on in-home polysomnography – relation to adult age and sex. Journal of Sleep Research 2017. doi: 10.1111/jsr.12626
DOI: https://doi.org/10.1111/jsr.12626

Tamm S, Nilsonne G, Lamm C, Kecklund G, Petrovic P, Fischer H, Åkerstedt T, Lekander M. The effect of sleep restriction on empathy for pain: An fMRI study in younger and older adults. Scientific Reports 2017 7:12236. doi: 10.1038/s41598-017-12098-9
DOI: https://doi.org/10.1038/s41598-017-12098-9

Tamm S, Nilsonne G, Schwarz J, Golkar A, Kecklund G, Petrovic P, Fischer H, Åkerstedt T, Lekander M. Sleep restriction caused impaired emotional regulation without detectable brain activation changes – a functional magnetic resonance imaging study. Royal Society Open Science, 6(3), 181704. doi: 10.1098/rsos.181704
DOI: https://doi.org/10.1098/rsos.181704

Nilsonne G, Tamm S, Schwarz J, Almeida R, Fischer H, Kecklund G, Lekander M, Fransson P, Åkerstedt T. Intrinsic brain connectivity after partial sleep deprivation in young and older adults: results from the Stockholm Sleepy Brain Study. Scientific Reports 2017 7:9422. doi: 10.1038/s41598-017-09744-7
DOI: https://doi.org/10.1038/s41598-017-09744-7

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