Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking

SND-ID: snd1084-1. Version: 1.0. DOI: https://doi.org/10.5878/eybp-ex91

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Citation

Creator/Principal investigator(s)

Morten Kraen - Lund University and Region Skåne

Research principal

Lund University

Description

Matrix metalloproteinases (MMP´s) are known biomarkers of atherosclerosis. MMP´s are also involved in the pathophysiological processes underlying chronic obstructive pulmonary disease (COPD). Cigarette smoking plays an important role in both disease states and is also known to affect the concentration and activity of MMP´s systemically. Unfortunately, the epidemiological data concerning the value of MMP´s as biomarkers of COPD and atherosclerosis with special regards to smoking habits are limited. Methods: 417 subjects with records of smoking habits and tobacco consumption were examined with comprehensive spirometry, carotid ultrasound examination and biomarker analysis of MMP-1, -3, -7, -10 and -12

Method and outcome

Data format / data structure

Numeric

Data collection

Geographic coverage

Administrative information

Ethics Review

Lund - Ref. 786-03 med komplettering för biomarköranalys 2015-03-11

Topic and keywords

Research area

Clinical medicine (Standard för svensk indelning av forskningsämnen 2011)

Keywords

Atherosclerosis, Pulmonary disease, chronic obstructive, Matrix metalloproteinase 3, Matrix metalloproteinase 1, Matrix metalloproteinase 7, Matrix metalloproteinase 10, Matrix metalloproteinase 12

Publications

Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking
M. Kraen, S. Frantz, U. Nihlén, G. Engström, C. G. Löfdahl, P. Wollmer & M. Dencker, 2019 Feb 21, In : PLoS ONE. 14, 2, e0211987.
DOI: https://doi.org/10.1371/journal.pone.0211987

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Published: 2019-02-06

Last updated: 2020-02-20