Effect of food intake on 92 biomarkers for cardiovascular disease
SND-ID: snd1024-1. Version: 1.0. DOI: https://doi.org/10.5878/002891
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Creator/Principal investigator(s)
Magnus Dencker - Skåne University Hospital, Malmö, Lund University
Research principal
Lund University
- Department of Medical Imaging and Physiology
Description
Objective: The present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease (CVD).
Methods: Twenty two healthy subjects (11 male and 11 female aged 25.9±4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 minutes afterwards with the Proseek Multiplex CVD III kit.
Results: The levels for eight biomarkers decreased significantly (P<0.05) 30 minutes after food intake. The levels for seven biomarkers remained significantly decreased 120 minutes after food intake. Nine biomarker decreased significantly at 120 minutes after food intake. The changes were between 4-30%, most commonly around 5%. Only six biomarkers showed a difference of 10% or more due to food intake. The biggest differences were observed for Insulin-like growth factor-binding protein 1 (30%); Azurocidin, Cystatin-B, and Myeloperoxidase (13%); Monocyte chemotactic protein 1 (11%); and Myeloblastin (10%), all 120 minutes after food intake.
Conclusions: This study shows that food intake affects several different CVD biomarkers, but the
Methods: Twenty two healthy subjects (11 male and 11 female aged 25.9±4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 minutes afterwards with the Proseek Multiplex CVD III kit.
Results: The levels for eight biomarkers decreased significantly (P<0.05) 30 minutes after food intake. The levels for seven biomarkers remained significantly decreased 120 minutes after food intake. Nine biomarker decreased significantly at 120 minutes after food intake. The changes were between 4-30%, most commonly around 5%. Only six biomarkers showed a difference of 10% or more due to food intake. The biggest differences were observed for Insulin-like growth factor-binding protein 1 (30%); Azurocidin, Cystatin-B, and Myeloperoxidase (13%); Monocyte chemotactic protein 1 (11%); and Myeloblastin (10%), all 120 minutes after food intake.
Conclusions: This study shows that food intake affects several different CVD biomarkers, but the effect is predominantly modest. Timing of blood sampling in relation to food intake, therefore, appears not to be a major concern. Further studies are warranted in older healthy subjects and in patients with various cardiac diseases to determine whether the findings are reproducible.
Purpose:
The present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease with the Proseek Multiplex CVD III kit. Show less..
Language
Unit of analysis
Population
Healty subjects
Time Method
Sampling procedure
Time period(s) investigated
2009-01 – 2009-09
Variables
281
Number of individuals/objects
22
Data format / data structure
Responsible department/unit
Department of Medical Imaging and Physiology
Ethics Review
Lund
Research area
Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)
Health (CESSDA Topic Classification)
Keywords
Dencker M. Effect of food intake on 92 biomarkers for cardiovascular disease. PONE-D-17-02534R1
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