Effect of food intake on 92 biomarkers for cardiovascular disease

SND-ID: snd1024-1. Version: 1.0. DOI: https://doi.org/10.5878/002891

Citation

Creator/Principal investigator(s)

Magnus Dencker - Skåne University Hospital, Malmö, Lund University

Research principal

Lund University - Department of Medical Imaging and Physiology rorId

Description

Objective: The present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease (CVD).
Methods: Twenty two healthy subjects (11 male and 11 female aged 25.9±4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 minutes afterwards with the Proseek Multiplex CVD III kit.
Results: The levels for eight biomarkers decreased significantly (P<0.05) 30 minutes after food intake. The levels for seven biomarkers remained significantly decreased 120 minutes after food intake. Nine biomarker decreased significantly at 120 minutes after food intake. The changes were between 4-30%, most commonly around 5%. Only six biomarkers showed a difference of 10% or more due to food intake. The biggest differences were observed for Insulin-like growth factor-binding protein 1 (30%); Azurocidin, Cystatin-B, and Myeloperoxidase (13%); Monocyte chemotactic protein 1 (11%); and Myeloblastin (10%), all 120 minutes after food intake.

Conclusions: This study shows that food intake affects several different CVD biomarkers, but the

... Show more..
Objective: The present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease (CVD).
Methods: Twenty two healthy subjects (11 male and 11 female aged 25.9±4.2 years) were investigated. A total of 92 biomarkers were measured before a standardized meal as well as 30 and 120 minutes afterwards with the Proseek Multiplex CVD III kit.
Results: The levels for eight biomarkers decreased significantly (P<0.05) 30 minutes after food intake. The levels for seven biomarkers remained significantly decreased 120 minutes after food intake. Nine biomarker decreased significantly at 120 minutes after food intake. The changes were between 4-30%, most commonly around 5%. Only six biomarkers showed a difference of 10% or more due to food intake. The biggest differences were observed for Insulin-like growth factor-binding protein 1 (30%); Azurocidin, Cystatin-B, and Myeloperoxidase (13%); Monocyte chemotactic protein 1 (11%); and Myeloblastin (10%), all 120 minutes after food intake.

Conclusions: This study shows that food intake affects several different CVD biomarkers, but the effect is predominantly modest. Timing of blood sampling in relation to food intake, therefore, appears not to be a major concern. Further studies are warranted in older healthy subjects and in patients with various cardiac diseases to determine whether the findings are reproducible.

Purpose:

The present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease with the Proseek Multiplex CVD III kit. Show less..

Language

Method and outcome

Unit of analysis

Population

Healty subjects

Time Method

Time period(s) investigated

2009-01 – 2009-09

Variables

281

Number of individuals/objects

22

Data format / data structure

Data collection
  • Mode of collection: Measurements and tests
  • Time period(s) for data collection: 2009-01 – 2009-09
  • Source of the data: Population group, Biological samples
Geographic coverage

Geographic spread

Geographic location: Sweden, Skåne County

Geographic description: Malmö

Administrative information

Responsible department/unit

Department of Medical Imaging and Physiology

Ethics Review

Lund

Topic and keywords

Research area

Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)

Health (CESSDA Topic Classification)

Publications

Dencker M. Effect of food intake on 92 biomarkers for cardiovascular disease. PONE-D-17-02534R1

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Published: 2017-05-29
Last updated: 2017-06-09