DIWA - Diabetes and Impaired glucose tolerance in Women and Atherosclerosis development study

SND-ID: ext0140-1.

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Creator/Principal investigator(s)

Göran Bergström - University of Gothenburg, The Sahlgrenska Academy, Institute of Medicine

Research principal

University of Gothenburg - Institute of Medicine rorId


All 64-year old women in the county of Gothenburg were invited to a screening examination including an OGTT. Glucose tolerance was defined for each participant according to the World Health Organization (WHO) criteria. Patients were divided in three sub-groups according to metabolic status and a randomized sample of patients were recruited from each group for a longitudinal follow-up study: diabetes mellitus (n = 220), impaired glucose tolerance (IGT, n = 204) or normal glucose tolerance (NGT, n = 188). Baseline examination was performed between 2002-2004 and follow-up examination in 2007-2009 (mean follow-up 5.5 years).
Datasets from papers published in open access is made available on request.


The aim of the DIWA-study is to investigate the development of atherosclerosis in women with different degrees of glucose control.
Method and outcome

Unit of analysis


64-year old women in Gothenburg (2002)

Sampling procedure

Time period(s) investigated

2002 – Ongoing

Biobank is connected to the study


Data format / data structure

Data collection

Data collection 1

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 2002 – 2004
  • Source of the data: Population group

Data collection 2

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 2007 – 2009
  • Source of the data: Population group
Geographic coverage

Geographic spread

Geographic description: Gothenburg

Administrative information

Responsible department/unit

Institute of Medicine

Topic and keywords

Research area

Endocrinology and diabetes (Standard för svensk indelning av forskningsämnen 2011)

Health (CESSDA Topic Classification)


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Fagerberg B, Prahl Gullberg U, Alm R, Nilsson J, Nordin Fredrikson G. Circulating autoantibodies against the apolipoprotein B-100 peptides p45 and p210 in relation to the occurrence of carotid plaques in 64-year-old women. PLoS ONE 2015;10(3): e0120744. doi:10.1371/journal.pone.0120744
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Bergström G, Fagerberg B, Sallsten G, Lundh T, Barregard L. Is cadmium exposure associated with the burden, vulnerability and rupture of human atherosclerotic plaques? PLOS ONE (in press).

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