BIG3

SND-ID: ext0129-1.

Is part of collection at SND: Scania Metadatabase for Epidemiology (SME)

Access to data via

Contact

Creator/Principal investigator(s)

Ulf Malmqvist - Region Skåne

Research principal

Region Skåne

Description

BIG3 is a Scanian research project in which the name BIG3 is aiming at three major diseases: chronic obstructive pulmonary disease (COPD), cardiovascular diseases and lung cancer. The overall goal of BIG3 is to understand the mechanisms underlying these diseases in order to develop new treatments that can lead to earlier, better and more accurate diagnosis for better and more individualized treatment. BIG3 is an open prospective longitudinal cohort study in Sweden.
As a first step, around 100 000 people in Scania between 45 and 75 years have the opportunity to answer a questionnaire about lifestyle, living environment and tobacco habits. Then about 10 000 individuals from the respondents will be summoned to undergo examinations. These include ECG, CT scan of the heart and lungs, pulmonary function tests and blood tests. The blood samples will be analyzed both directly for a number of markers and also stored in a biobank for later analysis. The goal is to try to get about 50% of smokers in the cohort.

Ultimately, the study aims to find out which individuals that are at greater risk of develo

... Show more..
BIG3 is a Scanian research project in which the name BIG3 is aiming at three major diseases: chronic obstructive pulmonary disease (COPD), cardiovascular diseases and lung cancer. The overall goal of BIG3 is to understand the mechanisms underlying these diseases in order to develop new treatments that can lead to earlier, better and more accurate diagnosis for better and more individualized treatment. BIG3 is an open prospective longitudinal cohort study in Sweden.
As a first step, around 100 000 people in Scania between 45 and 75 years have the opportunity to answer a questionnaire about lifestyle, living environment and tobacco habits. Then about 10 000 individuals from the respondents will be summoned to undergo examinations. These include ECG, CT scan of the heart and lungs, pulmonary function tests and blood tests. The blood samples will be analyzed both directly for a number of markers and also stored in a biobank for later analysis. The goal is to try to get about 50% of smokers in the cohort.

Ultimately, the study aims to find out which individuals that are at greater risk of developing one or more of the three diseases and why some individuals seem to be protected.

Purpose:
BIG3 aims to increase understanding and to reduce morbidity / mortality in chronic diseases such as COPD, lung cancer and cardiovascular diseases, and to improve the care and quality of life for individuals with these disorders. Show less..

Data contains personal data

Yes

Sensitive personal data

Yes

Method and outcome

Unit of analysis

Population

100 000 individuals between 45-77 years, residing in Scania.

Sampling procedure

Time period(s) investigated

2013 – Ongoing

Biobank is connected to the study

Yes

Data format / data structure

Data collection

Data collection 1

  • Mode of collection: Physical measurements and tests
  • Time period(s) for data collection: 2013–ongoing
  • Source of the data: Population group, Biological samples

Data collection 2

  • Mode of collection: Self-administered questionnaire
  • Time period(s) for data collection: 2013–ongoing
  • Source of the data: Population group, Biological samples
Geographic coverage

Geographic spread

Geographic description: Skåne

Administrative information

Ethics Review

Lund - Ref. 2011/371, 2012474, 2013/350, 2013/856 samt 2014/535

Topic and keywords

Research area

Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)

Clinical medicine (Standard för svensk indelning av forskningsämnen 2011)

Cancer and oncology (Standard för svensk indelning av forskningsämnen 2011)

Cardiac and cardiovascular systems (Standard för svensk indelning av forskningsämnen 2011)

Health (CESSDA Topic Classification)

Publications