BIG3
SND-ID: ext0129-1.
Is part of collection at SND: Scania Metadatabase for Epidemiology (SME)
Creator/Principal investigator(s)
Ulf Malmqvist - Region Skåne
Research principal
Description
BIG3 is a Scanian research project in which the name BIG3 is aiming at three major diseases: chronic obstructive pulmonary disease (COPD), cardiovascular diseases and lung cancer. The overall goal of BIG3 is to understand the mechanisms underlying these diseases in order to develop new treatments that can lead to earlier, better and more accurate diagnosis for better and more individualized treatment. BIG3 is an open prospective longitudinal cohort study in Sweden.
As a first step, around 100 000 people in Scania between 45 and 75 years have the opportunity to answer a questionnaire about lifestyle, living environment and tobacco habits. Then about 10 000 individuals from the respondents will be summoned to undergo examinations. These include ECG, CT scan of the heart and lungs, pulmonary function tests and blood tests. The blood samples will be analyzed both directly for a number of markers and also stored in a biobank for later analysis. The goal is to try to get about 50% of smokers in the cohort.
Ultimately, the study aims to find out which individuals that are at greater risk of develo
As a first step, around 100 000 people in Scania between 45 and 75 years have the opportunity to answer a questionnaire about lifestyle, living environment and tobacco habits. Then about 10 000 individuals from the respondents will be summoned to undergo examinations. These include ECG, CT scan of the heart and lungs, pulmonary function tests and blood tests. The blood samples will be analyzed both directly for a number of markers and also stored in a biobank for later analysis. The goal is to try to get about 50% of smokers in the cohort.
Ultimately, the study aims to find out which individuals that are at greater risk of developing one or more of the three diseases and why some individuals seem to be protected.
Purpose:
BIG3 aims to increase understanding and to reduce morbidity / mortality in chronic diseases such as COPD, lung cancer and cardiovascular diseases, and to improve the care and quality of life for individuals with these disorders. Show less..
Data contains personal data
Yes
Sensitive personal data
Yes
Unit of analysis
Population
100 000 individuals between 45-77 years, residing in Scania.
Time Method
Sampling procedure
Time period(s) investigated
2013 – Ongoing
Biobank is connected to the study
Yes
Data format / data structure
Geographic spread
Geographic description: Skåne
Ethics Review
Lund - Ref. 2011/371, 2012474, 2013/350, 2013/856 samt 2014/535
Research area
Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)
Clinical medicine (Standard för svensk indelning av forskningsämnen 2011)
Cancer and oncology (Standard för svensk indelning av forskningsämnen 2011)
Cardiac and cardiovascular systems (Standard för svensk indelning av forskningsämnen 2011)
Health (CESSDA Topic Classification)
Keywords
Dental health, Smoking, Sleep, Pregnancy, Cardiovascular diseases, Cancer, Medical history, Anthropometry, Blood specimen collection, Life style, Memory, Longitudinal studies, Prospective studies, Myocardial infarction, Alcohol drinking, Respiratory system, Cardiovascular diseases, Health status, Body weight, Lung neoplasms, Lung diseases, Menstruation, Social support, Respiratory tract diseases, Social networks, Scania, Epihealth, Work environment, Epihealth_skåne