Breast Cancer-metastases study

SND-ID: ext0122-1.

Is part of collection at SND: Scania Metadatabase for Epidemiology (SME)

Access to data via

Contact

Håkan Olsson

hakan.olsson@med.lu.se

Creator/Principal investigator(s)

Håkan Olsson - Lund University, Faculty of Medicine, The Division of Oncology and Pathology

Research principal

Region Skåne - Faculty of Medicine, The Division of Oncology and Pathology

Description

The participants in this cohort are individuals with breast cancer and metastatic disease coming to the Department of Oncology in Lund for treatment since 2003. The data collection in the study is still ongoing. From all individuals, there is information about the status of the primary tumor, metastatic sites, tumor volume, and treatments. There are also paraffin-embedded tissue from primary tumor saved from all individuals, and for a subset of the cohort also frozen primary tumor tissue saved. There is DNA, plasma and serum saved from all individuals.

Purpose:

To find tumor markers or tumor cells in the blood from patients with metastatic breast cancer.

Data collection was started in 2003 and is ongoing (in 2010 there were over 300 individuals included in the study).

Method and outcome

Unit of analysis

Individual

Population

Individuals with metastatic breast cancer, treated at the oncologist in Lund.

Time Method

Cross-section

Sampling procedure

Probability

Time period(s) investigated

2003 – Ongoing

Number of individuals/objects

310

Data format / data structure

Numeric

Data collection

Mode of collection: Physical measurements and tests
Time period(s) for data collection: 2003–ongoing
Source of the data: Registers/Records/Accounts: Administrative, Biological samples, Registers/Records/Accounts

Geographic coverage

Administrative information

Responsible department/unit

Faculty of Medicine, The Division of Oncology and Pathology

Topic and keywords

Research area

Clinical medicine (Standard för svensk indelning av forskningsämnen 2011)

Cancer and oncology (Standard för svensk indelning av forskningsämnen 2011)

Health (CESSDA Topic Classification)

Keywords

Cancer, Blood specimen collection, Neoplasms, Biomarkers, Breast neoplasms, Dna, Serum, Biomarkers, tumor, Plasma, Paraffin embedding, Tissue embedding, Scania, Epihealth, Epihealth_skåne, Frozen tissue

Publications

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Carlsson A, Wingren C, Ingvarsson J, Ellmark P, Baldertorp B, Fernö M, Olsson H, Borrebaeck CA. Serum proteome profiling of metastatic breast cancer using recombinant antibody microarrays. Eur J Cancer. 2008 Feb;44(3):472-80. doi: 10.1016/j.ejca.2007.11.025. Epub 2008 Jan 2.

Carlsson MC, Balog CI, Kilsgård O, Hellmark T, Bakoush O, Segelmark M, Fernö M, Olsson H, Malmström J, Wuhrer M, Leffler H. Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease. Biochim Biophys Acta. 2012 Sep;1820(9):1366-72. doi: 10.1016/j.bbagen.2012.01.007. Epub 2012 Jan 17.

Carlsson MC, Cederfur C, Schaar V, Balog CI, Lepur A, Touret F, Salomonsson E, Deelder AM, Fernö M, Olsson H, Wuhrer M, Leffler H. Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients. PLoS One. 2011;6(10):e26560. doi: 10.1371/journal.pone.0026560. Epub 2011 Oct 18.
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Carlsson A, Wingren C, Kristensson M, Rose C, Fernö M, Olsson H, Jernström H, Ek S, Gustavsson E, Ingvar C, Ohlsson M, Peterson C, Borrebaecka C A.K. Molecular serum portraits in patients with primary breast cancer predict the development of distant metastases. Proc Natl Acad Sci U S A. Aug 23, 2011; 108(34): 14252-14257. doi: 10.1073/pnas.1103125108. Published online Aug 15, 2011.
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