Fertility and female dietary exposure to persistent organochlorine compounds - The fishermen’s sisters
SND-ID: ext0068-2.
Is part of collection at SND: Scania Metadatabase for Epidemiology (SME)
Creator/Principal investigator(s)
Anna Axmon - Lund University, Laboratory medicine
Lars Hagmar - Lunds universitet, Avdelningen för arbets- och miljömedicin, Institutionen för laboratoriemedicin
Ulf Strömberg - Lund University and Region Skåne, Department of Occupation and Environmental Medicine,Department of Laboratory Medicine and och Occupation and Environmental Medicine, Laboratory Medicine Skåne
Lars Rylander - Lund University and Region Skåne, Department of Occupation and Environmental Medicine,Department of Laboratory Medicine and och Occupation and Environmental Medicine, Laboratory Medicine Skåne
Research principal
Lund University
- Department of Laboratory Medicine, Lund
Description
Animal studies have shown that exposure for PCBs, can effects the menstrual cycle and cause reduced fertility in females. In humans, fertility can be measured by examining the waiting time to pregnancy, ie the time between the time when a couple stop using contraception and the time when the woman becomes pregnant. This can be measured only if the pregnancy was planned. Once pregnancy has been established, it is possible to examine fetal survival by looking at miscarriage risk.
In Sweden consumption of fatty fish (such as salmon and herring) from the Baltic Sea is one of the major sources of exposure to PCB. It has previously been shown that Swedish fishermen and their families eats more fish than the general population.
In order to study the possible health effects of exposure to PCBs through consumption of fatty fish from the Baltic Sea, groups of fishermen from the Swedish east coast have been identified. By matching with different registers groups of wives and ex- wives of the fishermen (fishermen's wives), and groups of sisters and half-sisters (fish sisters) have been identified. As a
In Sweden consumption of fatty fish (such as salmon and herring) from the Baltic Sea is one of the major sources of exposure to PCB. It has previously been shown that Swedish fishermen and their families eats more fish than the general population.
In order to study the possible health effects of exposure to PCBs through consumption of fatty fish from the Baltic Sea, groups of fishermen from the Swedish east coast have been identified. By matching with different registers groups of wives and ex- wives of the fishermen (fishermen's wives), and groups of sisters and half-sisters (fish sisters) have been identified. As a reference population (non-exposed), corresponding groups have been identified among fishermen on the Swedish west coast.
Questionnaires were sent to the wives of fishermen and fish sisters to gather information about their first planned pregnancy. Besides waiting time to pregnancy questions were also asked about pregnancy outcomes in order to calculate the risk of miscarriage. The response rate in both groups was just under 60% (1090 West and 505 East Coast fishermen's wives, and 1103 West and 709 East Coast fish sisters). In 121 East Coast fisher wives and 165 East Coast fisher sisters blood samples were analyzed to determine the concentration of the CB 153. This concentration was then used as a measure of exposure to PCBs.
Purpose:
To investigate whether exposure to persistent organochlorine compounds through the consumption of fatty fish from the Baltic Sea leads to a decreased fertility, measured as time to pregnancy, to investigate whether the same exposure implies an increased miscarriage risk, and to assess the relation between blood levels of PCB and the reproductive outcomes time to pregnancy and miscarriages.
Here, only the first planned pregnancy of each woman was inquired about. The questions asked in the sister questionnaire were similar to those in the wife questionnaire. No information was collected on the women’s partners. The fishermen’s sisters were asked about their alcohol consumption, and if they at any point in their life had experienced a miscarriage. Of the 709 east coast fishermen’s sisters who replied to the first questionnaire, 203 women supplied a time to pregnancy as well as agreed to participate in further studies. These women were contacted and asked if they were willing to supply blood samples for analysis of CB-153. At the time of the blood sampling they were asked to fill out a second questionnaire regarding time to pregnancy and pregnancy outcome for all their pregnancies. Information was collected on the year of the pregnancy, use of contraceptives before conception, time to pregnancy, smoking habits, pregnancy outcome and, in case of live births, breast-feeding (months of breast-feeding only, breast-feeding together with additional formula, and breastfeeding combined with solids). In all, 286 fishermen’s wives and sisters had blood drawn and supplied a time to pregnancy Show less..
Data contains personal data
Yes
Sensitive personal data
Yes
Code key exists
Yes
Unit of analysis
Time Method
Time period(s) investigated
1999 – 1999
Number of individuals/objects
1812
Response rate/participation rate
58%
Data format / data structure
Geographic spread
Geographic description: The Swedish east and west coast
Responsible department/unit
Department of Laboratory Medicine, Lund
Research area
Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)
Health sciences (Standard för svensk indelning av forskningsämnen 2011)
Occupational health and environmental health (Standard för svensk indelning av forskningsämnen 2011)
Health (CESSDA Topic Classification)
Axmon A, Rylander L, Strömberg U, Jönsson B, Nilsson-Ehle P, Hagmar L. Polychlorinated biphenyls in serum and time to pregnancy. Environ Res. 2004 Oct;96(2):186-95.
Axmon A, Hagmar L. Time to pregnancy and pregnancy outcome.
Fertil Steril. 2005 Oct;84(4):966-74.
Axmon A, Rylander L, Strömberg U, Hagmar L. Female fertility in relation to the consumption of fish contaminated with persistent organochlorine compounds. Scand J Work Environ Health. 2002 Apr;28(2):124-32.
Axmon A, Rylander L, Rignell-Hydbom A. Reproductive toxicity of seafood contaminants: prospective comparisons of Swedish east and west coast fishermen's families. Environ Health. 2008 May 28;7:20. doi: 10.1186/1476-069X-7-20.
Axmon A, Rignell-Hydbom A. Association between biomarkers of exposure to persistent organochlorine compounds (POCs).
Chemosphere. 2006 Jul;64(4):692-4. Epub 2005 Dec 9.
Axmon A, Rylander L, Strömberg U, Dyremark E, Hagmar L. Polychlorinated biphenyls in blood plasma among Swedish female fish consumers in relation to time to pregnancy. J Toxicol Environ Health A. 2001 Nov 23;64(6):485-98.
Axmon A, Rignell-Hydbom A. Estimations of past male and female serum concentrations of biomarkers of persistent organochlorine pollutants and their impact on fecundability estimates. Environ Res. 2006 Jul;101(3):387-94. Epub 2005 Dec 13.
Axmon A, Rylander L, Strömberg U, Hagmar L. Miscarriages and stillbirths in women with a high intake of fish contaminated with persistent organochlorine compounds. Int Arch Occup Environ Health. 2000 Apr;73(3):204-8.
Axmon A, Rylander L, Strömberg U, Hagmar L. Time to pregnancy and infertility among women with a high intake of fish contaminated with persistent organochlorine compounds. Scand J Work Environ Health. 2000 Jun;26(3):199-206.
Axmon A, Rylander L, Strömberg U, Hagmar L. Altered menstrual cycles in women with a high dietary intake of persistent organochlorine compounds. Chemosphere. 2004 Aug;56(8):813-9.
Axmon A. Menarche in women with high exposure to persistent organochlorine pollutants in utero and during childhood.
Environ Res. 2006 Sep;102(1):77-82. Epub 2006 Feb 2.
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