Uppsala Longitudinal Study of Adult Men (ULSAM)
SND-ID: ext0051-1.
Is part of collection at SND: Swedish Cohort Consortium (Cohorts.se), Swedish Diet Cohort Consortium (SDCC)
Access to data via
Citation
Creator/Principal investigator(s)
Peter Nordström - Uppsala University, Department of Public Health and Caring Sciences
Research principal
Uppsala University - Department of Public Health and Caring Sciences
Description
Uppsala Longitudinal Study of Adult Men (ULSAM) is a unique, ongoing, longitudinal, epidemiologic study based on all available men, born between 1920 and 1924 and living in Uppsala County, Sweden. The aim of Uppsala Study of Adult Men (ULSAM) is to investigate the risk factors for common diseases, including biochemical markers, variations in the genome and life style factors.
ULSAM started as a health investigation, focused at identifying metabolic risk factors for cardiovascular disease, to which all 50 year-old men living in Uppsala in 1970 were invited. Of these, 82% (2322 men) participated in the investigation. The men were thereafter investigated again at ages 60, 70, 77, 82, 88 and 93 years. In the 93 years investigation, which was completed in spring 2015, even spouses to the men from original cohort have participated.
ULSAM is focused on several areas with a wide range of phenotypes collected. These areas include glucose and insulin metabolism, blood pressure, anthropometry, lipids and fatty acid composition, diet, cognitive function, socio-economic factors, heredity, medical histor
ULSAM started as a health investigation, focused at identifying metabolic risk factors for cardiovascular disease, to which all 50 year-old men living in Uppsala in 1970 were invited. Of these, 82% (2322 men) participated in the investigation. The men were thereafter investigated again at ages 60, 70, 77, 82, 88 and 93 years. In the 93 years investigation, which was completed in spring 2015, even spouses to the men from original cohort have participated.
ULSAM is focused on several areas with a wide range of phenotypes collected. These areas include glucose and insulin metabolism, blood pressure, anthropometry, lipids and fatty acid composition, diet, cognitive function, socio-economic factors, heredity, medical history, and common risk factors for cardiovascular disease. In the latest investigation we are particularly focusing on the factors leading to healthy ageing.
The longitudinal design of the study contributes to the collection of the same (or similar) phenotypes at several points in time. The loss of follow up end points is very low due to yearly matching with official cause-of-death and hospital discharge registries. Very important research area in ULSAM is analysis of genetic factors affecting common diseases. We have DNA samples available from more than 1200 men. Using modern genotyping technologies, these samples have been analyzed for over 2.5 million SNPs. We are also planning to perform whole genome sequencing for all individuals with DNA samples available.
Large number of researchers are using ULSAM data in their studies. ULSAM is involved in several international collaborations as well. Over 300 articles have been published from ULSAM initiation in 1970 and at least 30 doctoral theses explored data collected in our study. Show less..
Data contains personal data
Yes
Sensitive personal data
Yes
Type of personal data
The data are pseudonymized and contain indirect identifiers as well as different health, clinical and genetic data
Code key exists
Yes
Unit of analysis
Population
Men born 1920-1924 in Uppsala county
Time Method
Study design
Observational study
Sampling procedure
Time period(s) investigated
Biobank is connected to the study
This study has used existing samples from a scientific collection or biobank
Response rate/participation rate
Age 50: 2322 individuals
Age 60: 1860 individuals
Age 70: 1221 individuals
Age 77: 839 individuals
Age 82: 530 individuals
Age 88: 354 individuals
Age 93: 168 individuals
Data format / data structure
Lowest geographic unit
County (NUTS 3)
Highest geographic unit
County (NUTS 3)
Responsible department/unit
Department of Public Health and Caring Sciences
Ethics Review
Uppsala - Ref. Dnr 251/90
ULSAM-70: Dnr 251/90, godkänt 1991-08-21
Uppsala - Ref. Dnr 2013/350
ULSAM-93: Dnr 2013/350, godkänt 2013-10-23
Research area
Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)
Public health, global health, social medicine and epidemiology (Standard för svensk indelning av forskningsämnen 2011)
Health (CESSDA Topic Classification)
Keywords
Ageing, Blood pressure, Cohort studies, Health surveys, Dementia, Dyspnea, Residence characteristics, Life style, Medicine, Nursing care, Movement, Exercise, Muscular diseases, Osteoporosis, Urinary incontinence, Mortality, Neoplasms, Diet, Alcohol drinking, Chest pain, Diabetes mellitus, Leisure activities, Genetics, Cardiovascular diseases, Dietary supplements, Body weight, Angina pectoris, Lung diseases, Oral health, Smoking, Tobacco, smokeless, Dairy products, Family relations, Feeding behavior, Focus groups, Foods, specialized, Sedentary behavior, Lifestyle factors, Disabilities, Swedish cohort consortium (scc), Swedish diet cohort consortium (sdcc), Sdcc, Cohorts.se
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