The BAMSE project

SND-ID: ext0037-1.

Access to data via

Contact

Erik Melén

erik.melen@ki.se

Creator/Principal investigator(s)

Magnus Wickman - Karolinska Institutet, Institute of Environmental Medicine

Göran Pershagen - Karolinska Institutet, Institute of Environmental Medicine

Inger Kull - Karolinska Institutet, Institute of Environmental Medicine

Erik Melén - Karolinska Institutet, Institute of Environmental Medicine

Anna Bergström - Karolinska Institutet, Institute of Environmental Medicine

Research principal

Karolinska Institutet - Institute of Environmental Medicine rorId

Description

Both hereditary and environmental factors influence the risk of children developing lung- and allergy-related diseases, but how these factors affect the age of onset and prognosis has been little studied. Similarly, it is unknown which factors determine whether these diseases regress during childhood, remain mild, or worsen. A unified database that tracks lifestyle and allergic diseases from birth through adolescence is lacking both nationally and internationally.

Use of the infrastructure: From 1994 to 1996, over 4,000 children were born in pre-selected areas of Stockholm County. These children have been followed with repeated questionnaires and examinations as part of the BAMSE project (at ages 0, 1, 2, 4, 8, 12, 16, and 24 years). Additionally, the BAMSE COVID-19 follow-up study, initiated in August 2020, aims to investigate risk factors for COVID-19 and the long-term health consequences among young adults. In a new project, we also plan to study how allergic diseases affect the introduction to working life. We will collect information on work-related factors from the LISA register and the

... Show more..
Both hereditary and environmental factors influence the risk of children developing lung- and allergy-related diseases, but how these factors affect the age of onset and prognosis has been little studied. Similarly, it is unknown which factors determine whether these diseases regress during childhood, remain mild, or worsen. A unified database that tracks lifestyle and allergic diseases from birth through adolescence is lacking both nationally and internationally.

Use of the infrastructure: From 1994 to 1996, over 4,000 children were born in pre-selected areas of Stockholm County. These children have been followed with repeated questionnaires and examinations as part of the BAMSE project (at ages 0, 1, 2, 4, 8, 12, 16, and 24 years). Additionally, the BAMSE COVID-19 follow-up study, initiated in August 2020, aims to investigate risk factors for COVID-19 and the long-term health consequences among young adults. In a new project, we also plan to study how allergic diseases affect the introduction to working life. We will collect information on work-related factors from the LISA register and the MiDAS register for study participants who have not declined to allow their information to be collected from national and regional registers.

A large database with more than 6,000 variables containing all collected information has been gradually built up. A comprehensive national and international research collaboration has been established around environment and genetics in relation to the development of lung and allergic diseases within the framework of the project.

With data from the collected material, the development of allergic diseases has been described, as well as risk factors for allergic diseases and the consequences for quality of life due to such diseases. More than 300 scientific articles have been published, 42 doctoral dissertations and one licentiate thesis have been presented. Ongoing extensive work is being done to develop the database by adding and evaluating collected data, working with descriptions of individual and composite variables used by the various research groups, and developing epidemiological/statistical analysis techniques. With the help of epidemiology assistants and statisticians, high quality in the datasets used by different research groups is ensured.

New research opportunities: More than 30 senior researchers within KI, nationally outside KI, and internationally collaborate with the project. The project is part of a European collaboration involving several cohorts to achieve sufficient statistical power. Data on more than 30,000 children are included in the joint European database, to which BAMSE contributes data on 4,000 children. Several areas can be researched, but the main focus will be on lung and allergic diseases, environment, and genetics. Significant efforts are being made to make the database well-known and accessible to researchers. The structure of the BAMSE database is available on the internet across three sites.

Significance: Due to its population-based recruitment, repeated follow-ups with the collection of biological material throughout childhood and adolescence, low attrition, more than 6,000 variables, European collaboration, and the establishment of a joint database of more than 30,000 children, there are excellent opportunities for world-leading research aimed at preventing lung and allergic diseases and reducing the burden for those already affected.

Aim: The aim of the project is to study risk factors and how environment, lifestyle, and heredity influence the development of asthma and allergies. During the course of the project, the aim has expanded to also include other common public health diseases such as chronic obstructive pulmonary disease, obesity, and cardiovascular disease. Show less..

Language

Method and outcome

Unit of analysis

Population

Children and parents from selected areas in Stockholm County

Study design

Cohort study

Sampling procedure

All parents to children born in Järfälla, Solna, Sundbyberg, Vasastan and Norrmalm from Februari 1994 to November 1996 were asked by their pediatric clinic nurse to participate in the study.

Time period(s) investigated

1994 – Ongoing

Data format / data structure

Data collection

Data collection 1

  • Mode of collection: Self-administered questionnaire: paper
  • Description of the mode of collection:
    Questionnaire for guardians
    219 variables
    75% response rate (4089 out of 5488)
  • Time period(s) for data collection: 1994 – 1996
  • Sample size: 5488
  • Non response size: 1399
  • Source of the data: Population group

Data collection 2

  • Mode of collection: Self-administered questionnaire: paper
  • Description of the mode of collection:
    Questionnaire for guardians
    174 variables
    96% response rate
  • Time period(s) for data collection: 1995 – 1997
  • Sample size: 4089
  • Non response size: 165
  • Source of the data: Population group

Data collection 3

  • Mode of collection: Self-administered questionnaire: paper
  • Description of the mode of collection:
    Questionnaire for guardians
    176 variables
    96% response rate
  • Time period(s) for data collection: 1996 – 1998
  • Sample size: 4089
  • Non response size: 246
  • Source of the data: Population group
... Show more..

Data collection 1

  • Mode of collection: Self-administered questionnaire: paper
  • Description of the mode of collection:
    Questionnaire for guardians
    219 variables
    75% response rate (4089 out of 5488)
  • Time period(s) for data collection: 1994 – 1996
  • Sample size: 5488
  • Non response size: 1399
  • Source of the data: Population group

Data collection 2

  • Mode of collection: Self-administered questionnaire: paper
  • Description of the mode of collection:
    Questionnaire for guardians
    174 variables
    96% response rate
  • Time period(s) for data collection: 1995 – 1997
  • Sample size: 4089
  • Non response size: 165
  • Source of the data: Population group

Data collection 3

  • Mode of collection: Self-administered questionnaire: paper
  • Description of the mode of collection:
    Questionnaire for guardians
    176 variables
    96% response rate
  • Time period(s) for data collection: 1996 – 1998
  • Sample size: 4089
  • Non response size: 246
  • Source of the data: Population group

Data collection 4

  • Mode of collection: Physical measurements and tests
  • Description of the mode of collection:
    Damm
    PEF
    Blod, DNA
    Urin
  • Time period(s) for data collection: 1998 – 2000
  • Source of the data: Population group

Data collection 5

  • Mode of collection: Self-administered questionnaire: paper
  • Description of the mode of collection:
    Questionnaire for guardians
    324 variables
    91% response rate
  • Time period(s) for data collection: 1998 – 2000
  • Sample size: 4089
  • Non response size: 360
  • Source of the data: Population group

Data collection 6

  • Mode of collection: Physical measurements and tests
  • Description of the mode of collection:
    Spirometri
    Blod, DNA
  • Time period(s) for data collection: 2002 – 2004
  • Source of the data: Population group

Data collection 7

  • Mode of collection: Self-administered questionnaire: paper
  • Description of the mode of collection:
    Questionnaire for guardians
    725 variables
    84% response rate

    A dietary survey was also conducted with a 64% response rate.
  • Time period(s) for data collection: 2002 – 2004
  • Sample size: 4089
  • Non response size: 672
  • Source of the data: Population group

Data collection 8

  • Mode of collection: Self-administered questionnaire: paper
  • Description of the mode of collection:
    Questionnaire for guardians and children
    930 variables
    82% response rate
  • Time period(s) for data collection: 2006 – 2008
  • Sample size: 4089
  • Non response size: 720
  • Source of the data: Population group

Data collection 9

  • Mode of collection: Self-administered questionnaire: web based
  • Description of the mode of collection:
    Questionnaire for guardians and children
    296 variables
    79% response rate
  • Time period(s) for data collection: 2010 – 2012
  • Sample size: 4089
  • Non response size: 842
  • Source of the data: Population group

Data collection 10

  • Mode of collection: Physical measurements and tests
  • Description of the mode of collection:
    Spirometri
    Impulse Oscil.
    FeNO
    Blod, DNA, RNA
    Lapptest
  • Time period(s) for data collection: 2010 – 2012

Data collection 11

  • Mode of collection: Self-administered questionnaire: web based
  • Description of the mode of collection:
    Questionnaire for participating children (now adults)
    75% response rate
  • Time period(s) for data collection: 2018 – 2020
  • Sample size: 4089
  • Non response size: 1025
  • Source of the data: Population group

Data collection 12

  • Mode of collection: Physical measurements and tests
  • Description of the mode of collection:
    Klinisk undersökning
    Spirometri
    N2-utsköljning
    FeNO
    Blodtryck
    Blod
    Näsprov
    Urin
    Saliva
  • Time period(s) for data collection: 2018 – 2020
  • Source of the data: Population group
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Geographic coverage

Geographic spread

Geographic location: Sweden

Geographic description: Järfälla, Solna and Sundbyberg municipalities and the city districts Vasastan and Norrmalm i in the middle of Stockholm

Administrative information

Responsible department/unit

Institute of Environmental Medicine

Publications

Sort by name | Sort by year

Kull, Inger. Infant feeding and allergy in children. Doktorsavhandling, Karolinska institutet, Stockholm 2005

Wickman M, Melen E, Berglind N, Lennart Nordvall S, Almqvist C, Kull I, Svartengren M, Pershagen G. Strategies for preventing wheezing and asthma in small children. Allergy 2003; 58(8): 742-747.

Hallberg J., Anderson M., Wickman M., Svartengren M. Sex influences on lung function and medication in childhood asthma. Acta Pædiatrica, 2006; 95: 1191-1196

Ballardini N., Kull I., Lind T., Hallner E., Almqvist C., Ostblom E., Melén E., Pershagen G., Lilja G., Bergström A., Wickman M. Development and comorbidity of eczema, asthma and rhinitis to age 12 - data from the BAMSE birth cohort. Allergy 2012 Feb 16.

Westman M., Stjärne P., Asarnoj A., Kull I., van Hage M., Wickman M., Toskala E. Natural course and comorbidities of allergic and nonallergic rhinitis in children. Journal of Allergy and Clinical Immunology 2012 Feb;129(2):403-8.

Vrijheid M., Casas M., Bergström A., Carmichael A., Cordier S., Eggesbø M., Eller E., Fantini MP., Fernández MF., Fernández-Somoano A., Gehring U., Grazuleviciene R., Hohmann C., Karvonen AM., Keil T., Kogevinas M., Koppen G., Krämer U., Kuehni CE., Magnus P., Majewska R., Andersen AM., Patelarou E., Petersen MS., Pierik FH., Polanska K., Porta D., Richiardi L., Santos AC., Slama R., Sram RJ., Thijs C., Tischer C., Toft G., Trnovec T., Vandentorren S., Vrijkotte TG., Wilhelm M., Wright J., Nieuw

Gruzieva O., Bellander T., Eneroth K., Kull I., Melén E., Nordling E., van Hage M., Wickman M., Moskalenko V., Hulchiy O., Pershagen G. Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life. Journal of Allergy and Clinical Immunology 2012 Jan; 129(1): 240-6

Magnusson JÖ., Kull I., Mai XM., Wickman M., Bergström A. Early childhood overweight and asthma and allergic sensitization at 8 years of age. Pediatrics. 2012 Jan;129(1):70-6.

Panasevich S., Lindgren C., Kere J., Wickman M., Pershagen G., Nyberg F., Melén E. Interaction between early maternal smoking and variants in TNF and GSTP1 in childhood wheezing.
Clin Exp Allergy 2010 Mar;40(3):458-67.

Neumann A., Söderhäll C., Fölster-Holst R., Baurecht H., Harde V., Müller-Wehling K., Rodríguez E., Ruether A., Franke A., Wagenpfeil S., Novak N., Mempel M., Kalali BN., Allgaeuer M., Koch J., Gerhard M., Melén E., Wahlgren CF., Kull I., Stahl C., Pershagen G., Lauener R., Riedler J., Doekes G., Scheynius A., Illig T., von Mutius E., Schreiber S., Kere J., Kabesch M., Weidinger S. A comprahensive analysis of the COL29A1 gene does not support a role in eczema. Journal of Allergy and Clinical Imm

Rosenlund H., Kull I., Pershagen G., Wolk A., Wickman M., Bergström A. Fruit and vegetable consumption in relation to allergy: disease-related modification of consumption?
Journal of Allergy and Clinical Immunology 2011 May;127(5):1219-25.

Nydert P., Kimland E., Kull I., Lindemalm S. Over-the-counter drug use - estimations within the Swedish paediatric population. European Journal of Pediatrics 2011 May;170(5):583-8

Brew BK., Kull I., Garden F., Almqvist C., Bergström A., Lind T., Webb K., Wickman M., Marks GB. Breastfeeding, asthma and allergy: a tale of two cities Pediatric Allergy and Immunology 2012 Feb;23(1):75-82

Bunyavanich S., Melen E., Wilk JB., Granada M., Soto-Quiros ME., Avila L., Lasky-Su J., Hunninghake GM., Wickman M., Pershagen G., O'Connor GT., Weiss ST., Celedón JC.
Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma. Clinical and Molecular Allergy 2011 Jan 18;9:1

Asarnoj A., Movérare R, Ostblom E., Poorafshar M., Lilja G., Hedlin G., van Hage M., Ahlstedt S., Wickman M. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds. Allergy 2010 Sep;65(9):1189-95.

Asarnoj A., Östblom E., Ahlstedt S., Hedlin G., Lilja G., van Hage M., Wickman M. Reported symptoms to peanut between 4 and 8 years among children sensitized to peanut and birch pollen - results from the BAMSE birth cohort. Allergy 2010; 65: 213-219

Saarne T., Grönlund H., Kull I., Almqvist C., Wickman M., van Hage M. Cat sensitization identified by recombinant Fel d 1 several years before symptoms - results from the bamse cohort. Pediatric Allergy and Immunology 2010; 21: 277-283

Hallberg J., Anderson M., Wickman M., Svartengren M. Factors in Infancy and Childhood Related to Reduced Lung Function in Asthmatic Children: A Birth Cohort Study (BAMSE). Pediatric Pulmonology 2010; 45: 341-348

Donner J., Haapakoski R., Ezer S., Melén E., Pirkola S., Gratacòs M., Zucchelli M., Anedda F., Johansson L. E., Söderhäll C., Orsmark-Pietras C., Suvisaari J., Martín-Santos R., Torrens M., Silander K., Terwilliger J. D., Wickman M., Pershagen G., Lönnqvist J., Peltonen L., Estivill X., D'Amato M., Kere J., Alenius H., Hovatta I. Assessment of the Neuropeptide S System in Anxiety Disorders. Biological Psychiatry 2010;68:474-483

Böhme M., Kull I., Bergström A., Wickman M., Nordvall L., Pershagen G., Wahlgren CF. Parental smoking increases the risk for eczema with sensitization in 4-year-old children. Journal of Allergy and Clinical Immunology 2010 Apr;125(4):941-3.

Marmsjö K., Rosenlund H., Kull I., Håkansson N., Wickman M., Pershagen G., Bergström A.
Use of multivitamin supplements in relation to allergic disease in 8-y-old children. The American Journal of Clinical Nutrition 2009 Dec;90(6):1693-8.

Hunninghake GM., Cho MH., Tesfaigzi Y., Soto-Quiros ME., Avila L., Lasky-Su J., Stidley C., Melén E., Söderhäll C., Hallberg J., Kull I., Kere J., Svartengren M., Pershagen G., Wickman M., Lange C., Demeo DL., Hersh CP., Klanderman BJ., Raby BA., Sparrow D., Shapiro SD., Silverman EK., Litonjua AA., Weiss ST., Celedón JC. MMP12, lung function, and COPD in high-risk populations. The New England Journal of Medicine 2009 Dec 31;361(27):2599-608

Janzi M., Kull I., Sjöberg R., Wan J., Melén E., Bayat N., Östblom E., Pan-Hammarström Q., Nilsson P., Hammarström L. Selective IgA deficiency in early life: Association to infections and allergic diseases during childhood. Clinical Immunology 2009; 133: 78-85

Panasevich S., Leander K., Rosenlund M., Ljungman P., Bellander T., de Faire U., Pershagen G., Nyberg F. Associations of long- and short-term air pollution exposure with markers of inflammation and coagulation in a population sample. Occup Environ Med. 2009 Nov;66(11):747-53.

Melén E., Nyberg F., Lindgren CM., Berglind N., Zucchelli M., Nordling E., Hallberg J., Svartengren M., Morgenstern R., Kere J., Bellander T., Wickman M., Pershagen G. Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Environmental Health Perspectives 2008 Aug;116(8):1077-84.

Nordling E., Berglind N., Melén E., Emenius G., Hallberg J., Nyberg F., Pershagen G., Svartengren M., Wickman M., Bellander T. Traffic-related air pollution and childhood respiratory symptoms, function and allergies. Epidemiology 2008 May;19(3):401-8

Asarnoj A., Östblom E., Kull I., Lilja G., Pershagen G., Hedlin G., van Hage M., Wickman M.
Sensitization to inhalant allergens between 4 and 8 years of age is a dynamic process: results from the BAMSE birth cohort. Clinical and Experimental Allergy 2008; 38: 1507-1513

Mai X.-M., Neuman Å., Östblom E., Pershagen G., Nordvall L., Almqvist C.,
van Hage M., Wickman M. Symptoms to pollen and fruits early in life and allergic disease at 4 years of age. Allergy 2008; 63: 1499-1504

Lannerö E., Wickman M., van Hage M., Bergström A., Pershagen G., Nordvall.L. Exposure to environmental tobacco smoke and sensitisation in children. Thorax 2008; 63: 172-176

Östblom E., Egmar A.-C., Gardulf A., Lilja G., Wickman M. The impact of food hypersensitivity reported in 9-year-old children by their parents on health-related quality of life. Allergy 2008: 63: 211-218

Mai X-M., Almqvist C., Nilsson L., Wickman M. Birth anthropometric measures, body mass index and allergic diseases in a birth cohort study (BAMSE). Archives of Disease in Childhood 2007; 92: 881-886

Kull I., Bergström A., Melén E., Lilja G., van Hage M., Pershagen G., Wickman M. Early-life supplementation of vitamins A and D, in water-soluble form or in peanut oil, and allergic diseases during childhood. Journal of Allergy and Clinical Immunology 2006 Dec;118(6):1299-304.

Lannerö E., Pershagen G., Wickman M., Nordvall L. Maternal smoking during pregnancy increases the risk of recurrent wheezing during the first years of life (BAMSE). Respiratory Research -On line. 2006; 7:3

Ghunaim N., Wickman M., Almqvist C., Söderström L., Ahlstedt S., van Hage M. Sensitization to different pollens and allergic disease in 4-year-old Swedish children. Clinical and Experimental Allergy 2006; 36: 722-727

Kull I., Bergström A., Lilja G., Pershagen G., Wickman M. Fish consumption during the first year of life and development of allergic diseases during childhood. Allergy 2006; 61: 1009-1015.

Melén E., Umerkajeff S., Nyberg F., Zucchelli M., Lindstedt A., Gullstén H., Wickman M., Pershagen G., Kere J. Interaction between variants in the interleukin-4 receptor a and interleukin-9 receptor genes in childhood wheezing: evidence from a birth cohort study. Clinical and Experimental Allergy 2006; 36: 1391-1398

Wickman M., Lilja G., Söderström L., van Hage-Hamsten M., Ahlstedt S. Quantitative analysis of IgE antibodies to food and inhalant allergens in 4-year-old children reflects their likelihood of allergic disease. Allergy 2005: 60: 650-657

Almqvist C., Pershagen G., Wickman M. Low socioeconomic status as a risk factor for asthma, rhinitis and sensitisation at four years in a birth cohort. Clinical and Experimental Allergy 2005; 35:612-618

Kull I., Bohme M., Wahlgren CF., Nordvall L., Pershagen G., Wickman M. Breast-feeding reduces the risk for childhood eczema. Journal of Allergy and Clinical Immunology 2005; 116:657-61

Melén E., Bruce S., Doekes G., Kabesch M., Laitinen T., Lauener R., Lindgren C. M., Riedler J., Scheynius A., van Hage-Hamsten M., Kere J., Pershagen G., Wickman M., Nyberg F., and the PARSIFAL Genetics Study Group. Haplotypes of G Protein-coupled Receptor 154 Are Associated with Childhood Allergy and Asthma. American Journal of Respiratory and Critical Care Medicine 2005; 171

Sidorchuk A., Wickman M., Pershagen G., Lagarde F., Linde A. Cytomegalovirus infection and development of allergic diseases in early childhood: interaction with EBV infection? Journal of Allergy and Clinical Immunology 2004 Dec;114(6):1434-40

Melén E, Kere J, Pershagen G, Svartengren M, Wickman M. Influence of male sex and parental allergic disease on childhood wheezing: role of interactions. Clinical and Experimental Allergy 2004 Jun;34(6):839-44.

Emenius G, Svartengren M, Korsgaard J, Nordvall L, Pershagen G, Wickman M. Building characteristics, indoor air quality and recurrent wheezing in very young children (BAMSE).
Indoor Air 2004; 14: 34-42.

Kull I, Lilja G, Almqvist C, Pershagen G, Wickman M. Breastfeeding reduces the risk of asthma during the first four years of life. Journal of Allergy and Clinical Immunology 2004, 114; 755-760.

Emenius G., Svartengren M., Korsgaard J., Nordvall L., Pershagen G., Wickman M. Indoor exposures and recurrent wheezing in infants: a study in the BAMSE cohort. Acta Pædiatrica 2004; 93: 899-905

Wickman, M. Experience with quantitative IgE antibody analysis in relation to allergic disease within the BAMSE birth cohort - towards an improved diagnostic process. Allergy 2004; 59 (Suppl. 78): 30-31

Sidorchuk A., Lagarde F., Pershagen G., Wickman M., Linde A. Epstein-Barr virus infection is not associated with development of allergy in children. The Pediatric Infectious Disease Journal 2003 Jul;22(7):642-7

Wickman M, Ahlstedt S, Lilja G, van Hage-Hamsten M. Quantification of IgE antibodies simplifies the classification of allergic diseases in 4-year-old children. A report from the prospective birth cohort study - BAMSE. Pediatric Allergy and Immunology 2003; 14: 441-447.

Almqvist C, Egmar AC, Hedlin G, Lundqvist M, Nordvall S, Pershagen G, Svartengren M, Hage-Hamsten M, Wickman M. Direct and indirect exposure to pets - risk of sensitization and asthma at 4 years in birth cohort. Clinical and Experimental Allergy 2003; 33: 1190-1197.

Almqvist C, Egmar AC, van Hage-Hamsten M, Berglind N, Pershagen G, Nordvall SL, et al.
Heredity, pet ownership, and confounding control in a population-based birth cohort. Journal of Allergy and Clinical Immunology 2003; 111: 800-6

Emenius G, Pershagen G, Berglind N, Kwon HJ, Lewné M, Nordvall L, Wickman M. NO2, as a marker of air pollution, and recurrent wheezing in children - a nested case-control study within the BAMSE birth cohort. Occupupational and Environmental Medicine 2003; 60(11): 876-81.

Wickman M, Kull I, Pershagen G, Nordvall SL. The BAMSE project: presentation of a prospective longitudinal birth cohort study. Pediatric Allergy and Immunology 2002; 13(Suppl. 15): 11-13.

Lannerö E, Kull I, Tollin L, Pershagen G, Wickman M, Nordvall L. Environmental risk factors for allergy and socio-economic status in a birth cohort (BAMSE). Pediatric Allergy and Immunology 2002; 13: 182-187

Böhme M, Lannerö E, Wickman M, Nordvall S, Wahlgren C. Atopic dermatitis and concomitant disease patterns in children up to two years of age. Acta Dermato Venereologica 2002; 82: 98-103

Kull I , Wickman M, Lilja G, Nordvall SL, Pershagen G. Breast feeding and allergic diseases in infants - a prospective birth cohort study (BAMSE). Archives of Disease in Childhood 2002; 87: 478-481.

Böhme M, Svensson Å, Kull I, Nordvall SL, Wahlgren CF. Clinical features of atopic dermatitis at two years of age: A prospective, population-based case-control study.
Acta Derm Venereol 2001; 81:193-197.

Böhme M, Svensson Å, Kull I, Wahlgren CF. Hanfin's and Rajka's minor criteria for atopic dermatitis: Which do 2-year-olds exhibit?J Am Acad Dermatol 2000; 43:785-792.

Janzi, Magdalena. Development of screening for primary immunodeficiency. Thesis, Karolinska Institutet 2009

Roll Bennet, Petra. Doing Parenthood' and Child Health: Parents' understandings and narratives of child eczema.
Thesis, Stockholms university 2006

Panasevich, Sviatlana. Air pollution, genetic susceptibility and inflammation - Focusing on cardiovascular effects in adults and respiratory effects in children. Thesis, Karolinska Institutet, Stockholm 2011

Rosenlund, Helene. Protective factors in childhood allergy related to diet and lifestyle. Thesis, Karolinska Institutet, Stockholm 2010

Saarne, Tiiu. Recombinant cat and mite allergens as tools in the study of diagnosis and treatment of allergy. Thesis, Karolinska Institutet, Stockholm 2008

Östblom, Eva. Symptoms of food hypersensitivity in relation to sensitization to food and health-related quality of life in children. Thesis, Karolinska institutet, Stockholm 2008

Lannerö, Eva. Parental smoking, wheezing and sensitisation in early childhood. Thesis, Karolinska institutet, Stockholm 2008

Hallberg, Jenny. Factors associated with lung function impairment in children and adults with obstructive lung disease. Thesis, Karolinska Institutet 2008.

Sidorchuck, Anna. Environmental and lifestyle factors, including viral infections, in relation to development of allergy among children in Saint-Petersburg and Stockholm. Thesis, Karolinska Institutet 2007

Melén, Erik. Genetic studies on childhood asthma and allergy : Role of interactions. Thesis, Karolinska institutet, Stockholm 2006

Egmar, Ann-Charlotte. Katten också! Exponering för pälsdjur och dess konsekvenser för pälsdjursallergiska barn. Thesis, Karolinska institutet, Stockholm 2005

Ghunaim, Nariman.The use of allergen-specific IgE in the diagnosis of pollenrelated food allergy. Licentiatavhandling, Karolinska Institutet 2004

Emenius Gunnel. Indoor environment and recurrent wheezing in young children. Thesis, Karolinska Institutet Stockholm 2003

Normann, Erik. Chlamydia pnemoniae in Children, Epidemiology and Clinical Implications. Thesis, Uppsala University 2003

Almqvist, Catarina. Cat and dog allergens: Dispersal, exposure and health effects in childhood. Thesis, Karolinska Institutet 2002

Böhme, Maria. Atopic dermatitis: Clinical and epidemiological aspects in children up to four years. Thesis, Karolinska Institutet 2002

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