Data for: Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy

SND-ID: 2024-480. Version: 1. DOI: https://doi.org/10.5878/j3eq-7y09

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Associated documentation

240919_List of variables and definitions.xlsx (102.76 KB)

Citation

Creator/Principal investigator(s)

Ingegerd Adlerberth - University of Gothenburg, Institute of Biomedicine

Agnes Wold - University of Gothenburg, Institute of Biomedicine

Bill Hesselmar - University of Gothenburg, Institute of Clinical Sciences

Research principal

University of Gothenburg - Institute of Biomedicine, Department of Infectious Diseases; Institute of Clinical Sciences; Institute of Medicine

Description

These data underly a study which described longitudinal gut microbiota development during early childhood, and investigated associations with early life exposures and allergy outcomes.

The dataset includes variables on:

Host factors and early life exposures: sex, parental allergy, farm residence, pet ownership, and breastfeeding

Gut microbiota development: presence and population counts of selected bacterial groups at 9 timepoints between 3 days and 18 months of age. These data were obtained using quantitative bacterial culture of fecal samples, targeting key facultative and anaerobic bacteria of the infant gut (exception: samples obtained at 3 days of age were not cultured quantitatively and targeted facultative bacteria only).

Allergy at 3 and 8 years of age: clinical diagnosis of allergy (eczema, food allergy, allergic rhinoconjunctivitis or asthma)

Data contains personal data

Yes

Sensitive personal data

Yes

Type of personal data

Pseudonymized health data

Code key exists

Yes

Language

English

Method and outcome

Unit of analysis

Individual/Patient

Population

Children participating in the FARMFLORA birth cohort study. Around half of these children lived on a farm and half in the same rural area. The study followed the children from birth up to 8 years of age.

Time Method

Longitudinal: Cohort/Event-based

Study design

Cohort study: Prospective

Sampling procedure

The aim of the FARMFLORA study was to map which factors in the farming environment protect against allergy development. The FARMFLORA birth cohort included 65 children of whom 28 lived on dairy farms and 37 lived in a rural area but not on a farm in the Västra Götaland region in South-West Sweden. Recruitment to the cohort occurred between September 2005 and March 2008, by approaching pregnant women at maternity clinics in the study area. The children included were born at ≥38 weeks of gestation.

Time period(s) investigated

2005-09 – 2015-05

Variables

237

Number of individuals/objects

Data format / data structure

Numeric

Data collection

Description of the mode of collection:
Fecal samples were collected from children on nine occasions from 3 days to 18 months of age. The samples were subjected to quantative bacterial culture, and key bacteria of the infant gut were identified and quantified (exception: samples obtained at 3 days of age were not cultured quantitatively).

Data on farm residence, pets in the household and parental allergy were registered upon inclusion

Data on breastfeeding was registered by the parents and collected by telephone interviews

Allergy was diagnosed by clinical evaluation of children using set diagnostic criteria for atopic eczema, food allergy, asthma or allergic rhinoconjunctivitis by experienced pediatricians at three and eight years of age
Time period(s) for data collection: 2005-09 – 2015-05

Geographic coverage

Geographic spread

Geographic location: Västra Götaland County

Administrative information

Responsible department/unit

Institute of Biomedicine, Department of Infectious Diseases; Institute of Clinical Sciences; Institute of Medicine

Contributor(s)

Annika Ljung - University of Gothenburg

Monica Gio-Batta - University of Gothenburg

Anna-Carin Lundell - University of Gothenburg

Funding 1

Funding agency: Region Västra Götaland (agreement concerning medical research and education – ALF)
Funding agency's reference number: ALFGBG966243

Funding 2

Funding agency: Region Västra Götaland (agreement concerning medical research and education – ALF)
Funding agency's reference number: ALFGBG720181

Funding 3

Funding agency: Swedish Medical Research Council
Funding agency's reference number: K98-06X-12612-01A

Funding 4

Funding agency: Health & Medical Care Committee of the Region Västra Götaland (Regional Research & Development funds Västra Götaland region)
Funding agency's reference number: VGFOUREG-12007

Ethics Review

Gothenburg - Ref. 363-05

Gothenburg - Ref. 674-14

Topic and keywords

Research area

Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)

Health (CESSDA Topic Classification)

Keywords

Child, Pets, Hypersensitivity, Breast feeding, Bacteria, Infant, Intestines, Colony count, microbial, Gastrointestinal microbiome, Birth cohort

Publications

Ljung A, Gio-Batta M, Hesselmar B, Imberg H, Rabe H, et al. (2024) Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy. PLOS ONE 19(11): e0313078. https://doi.org/10.1371/journal.pone.0313078
DOI: https://doi.org/10.1371/journal.pone.0313078

Published: 2024-11-27