A twin study on health and behavior in young adult twins born between 1985 and 1992 was conducted. The aim of the study was to examine how genetic and environmental factors influences diseases. The study included questions about gastrointestinal disorders, pulmonary disease, asthma/allergy, arthritis, affective disorders and symptoms, eating disorders , fibromyalgia, chronic fatigue syndrome and women's health. The sample consisted of both identical (monozygotic) and fraternal (dizygotic) twins, including same-sex and opposite-sex pairs. Conducted in 2013, the study had a total of 6,870 participants out of 16,244 invited.

Participants were also asked to provide DNA samples via saliva for zygosity determination and genotyping. A total of 4,000 twins who participated in the YATSS survey were genotyped.

The YATSS study includes the following question areas:
ADHD
Alcohol
Allergy
Autism
Burnout
CES-D - Center for Epidemiologic Studies Depression Scale -11 items, Iowa Form
Chronic fatigue syndrome
DCQ - Dysmorphic Concerns Questionnaire (BDD) - 7 items, swedish version
Demography
MDD - Major Depressive Disorder - 31 items
Eatingdisorders
Education and occupation
Epilepsy
EPQ - Eysenck Personality Questionnaire - 9 items
Fibromyalgia
GAD - Generalised Anxiety Disorder - 19 items
Headache
Hoarding - HRS-I (Hoarding Rating Scale-Interview) - 4 out of 5 items
IBS - Irritable Bowel Syndrome
Illicit drugs
Medical history
Menstruation och reproductive history
OA & RA - Osteoarthritis and Rheumatoid arthritis
OCD - Obsessive Cumpulsive Disorder - 12 items
Physical activity
Performance
Psychosis
Reflux
Sexual risk behavior
SIL - sick leave
Sleep
Smoking and snuff use
Trauma
Urinary tract infection
Socio-economic index - classifation mainly based on information about individuals profession Show less..

Data contains personal data

Yes

Sensitive personal data

Yes

Type of personal data

Pseudonymised, health data, social security number, lifestyle, exposures, names, addresses, survey responses

Code key exists

Yes

Language

English

Swedish

Method and outcome

Unit of analysis

Individual/Patient

Population

Twins born in Sweden between 1985-05-01 and 1992-06-30

Time Method

Cross-section

Longitudinal: Cohort/Event-based

Study design

Cohort study

Description of study design

Data collection was conducted via a web survey, but also via paper questionnaires if participants desired it. Participation in the study was based on informed consent.

Sampling procedure

The sample was based on all twins born in Sweden between May 1985 and June 1992 according to the Medical Birth Registry (the National Board of Health and Welfare). Twins who had declined further participation in the twin registry, had protected identity, had emigrated, or had died were excluded. Both complete twin pairs and individual twins were invited to participate in the study.

Biobank is connected to the study

The study has collected samples/material which are stored in a scientific collection or biobank

Scientific collection or biobank name: KI Biobank

Type(s) of sample: DNA from saliva

Variables

1130

Number of individuals/objects

6870

Response rate/participation rate

42%

Out of 16,244 invited participants, 6,870 responded, resulting in a response rate of 42%.

Data format / data structure

Numeric

Text

Data collection

Mode of collection: Self-administered questionnaire
Description of the mode of collection: Paper or web questionnaire
Time period(s) for data collection: 2013-03 – 2014-01
Data collector: Karolinska Institutet
Instrument: CES-D (Structured questionnaire)
The CES-D scale is used to rate how often over the past week respondents experienced symptoms associated with depression, such as restless sleep, poor appetite, and feeling lonely.
DOI: 10.1177/089826439300500202
DOI: 10.1177/014662167700100306
Instrument: DCQ (Structured questionnaire)
The DCQ is a self-report measure with seven items which ask about cognitive and behavioural aspects of dysmorphic concern. See document YATSS_Instrument_DCQ_svensk.pdf
DOI: 10.3109/00048679809062719
DOI: 10.1046/j.1440-1614.2001.00860.x
DOI: 10.3109/00048671003596055
Instrument: OCD (Structured questionnaire)
A scale that measures symptoms of obsessive-compulsive disorder.
DOI: 10.1037//1040-3590.14.4.485
Instrument: HRS-I (Structured questionnaire)
A five-item semi-structured interview that assesses the features of compulsive hoarding (clutter, difficulty discarding, acquisition, distress and impairment).
DOI: 10.1016/j.psychres.2009.05.001
Instrument: MDD (Structured questionnaire)
Major Depressive Disorder
Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR; APA, 2000).
Source of the data: Registers/Records/Accounts: Medical/Clinical, Registers/Records/Accounts

Geographic coverage

Geographic spread

Geographic location: Sweden

Geographic description: Nationwide

Administrative information

Responsible department/unit

Department of Medical Epidemiology and Biostatistics / The Swedish Twin Registry

Funding

Funding agency: Karolinska Institutet
Funding information: Government grants

Ethics Review

Stockholm - Ref. 2012/2107-31/3

Ethics application approved on 9th of January 2013

Topic and keywords

Research area

Drug abuse, alcohol and smoking (CESSDA Topic Classification)

Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)

Public health, global health, social medicine and epidemiology (Standard för svensk indelning av forskningsämnen 2011)

Reproductive health (CESSDA Topic Classification)

General health and well-being (CESSDA Topic Classification)

Physical fitness and exercise (CESSDA Topic Classification)

Diet and nutrition (CESSDA Topic Classification)

Psychology (CESSDA Topic Classification)

Keywords

Health, Genetics, Twins, Phenotype, Identical twins, Zygosity

Publications

Ivanov, V. Z., Nordsletten, A., Mataix-Cols, D., Serlachius, E., Lichtenstein, P., Lundström, S., Magnusson, P. K. E., Kuja-Halkola, R., & Ruck, C. (n.d.). Heritability of hoarding symptoms across adolescence and young adulthood: A longitudinal twin study. In PLoS ONE (No. e0179541; Vol. 12, Issue 6). https://doi.org/10.1371/journal.pone.0179541
DOI: https://doi.org/10.1371/journal.pone.0179541
SwePub: oai:gup.ub.gu.se/255524

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