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Effects of early treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) on the bronchoalveolar lavage proteome and oxylipids during Bovine respiratory syncytial virus (BRSV) infection

SND-ID: 2024-458. Version: 1. DOI: https://doi.org/10.5878/5hzt-ps44

Citation

Alternative title

Effect of NSAIDs on the pulmonary proteome and oxylipids during BRSV infection

Creator/Principal investigator(s)

Sara Hägglund - Swedish University of Agricultural Sciences, Department of Clinical Sciences orcid

Jean Francois Valarcher - Swedish University of Agricultural Sciences, Department of Clinical Sciences orcid

Research principal

Swedish University of Agricultural Sciences - Department of Clinical Sciences rorId

Principal's reference number

SLU.klinvet.2024.4.4.IÄ-7

Description

Proteins and oxylipids in plasma and bronchoalveolar lavage (BAL), of calves treated against bovine respiratory syncytial virus infection, with meloxicam (MEL, n=5), aspirin (ASA, n=5), or not (CTR, n=5, untreated controls). Proteins and oxylipids were detected by label-free quantitative mass spectrometry-based proteomics and liquid chromatography/tandem mass spectrometry with triple quadrupole mass detectors, respectively. The design and methods of this trial is described in detail in Hägglund et al. 2024.

Data files:
2024-08-24_proteomic_oxilipids_BRSV_to_NDS_BAL_oxylipids_pg_ml.tsv: 31 rows × 26 columns
2024-08-24_proteomic_oxilipids_BRSV_to_NDS_BAL_proteins_LFQ.tsv: 797 rows × 32 columns
2024-08-24_proteomic_oxilipids_BRSV_to_NDS_plasma_oxylipids_pg_ml.tsv: 45 rows × 32 columns

Data contains personal data

No

Language

Method and outcome

Population

Calves treated against bovine respiratory syncytial virus infection, with meloxicam (MEL, n=5), aspirin (ASA, n=5), or not (CTR, n=5, untreated controls).

Time Method

Study design

Experimental study

Description of study design

For a complete description of the experimental design, please see Hägglund et al 2024.

Data format / data structure

Data collection
Geographic coverage
Administrative information

Responsible department/unit

Department of Clinical Sciences

Funding

  • Funding agency: FORMAS rorId
  • Funding agency's reference number: 2016-01770_Formas
  • Project name on the application: Nya behandlingsmetoder för luftvägssjukdom hos nötkreatur
  • Funding information: https://www.vr.se/english/swecris.html#/project/2016-01770_Formas

Ethics Review

Uppsala - Ref. 5.8.18-13628_2021

Topic and keywords

Research area

Respiratory medicine and allergy (Standard för svensk indelning av forskningsämnen 2011)

Health sciences (Standard för svensk indelning av forskningsämnen 2011)

Agricultural and veterinary sciences (Standard för svensk indelning av forskningsämnen 2011)

Keywords

Respiratory tract diseases, Bovine respiratory disease complex, Meloxicam, Acetylsalicylat-dl-lysin, Bovine respiratory syncytial virus, Cattle, Bos taurus

Publications
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License

CC BY 4.0

Versions

Version 1. 2024-09-12

Version 1: 2024-09-12

DOI: https://doi.org/10.5878/5hzt-ps44

Contact for questions about the data

SLU Arkiv

arkiv@slu.se

Published: 2024-09-12