Dataset investigating potential quantitative and qualitative differences in brain serotonergic activity between women with Premenstrual Dysphoria (PMD) and asymptomatic controls.

Positron-emission tomography with the immediate precursor of serotonin, 5-hydroxytryptophan (5-HTP), radiolabelled by 11C in the beta-3 position, was performed in the follicular and luteal phases for 12 women with PMD and 8 control women. Brain radioactivity–a proxym for serotonin precursor uptake and synthesis–was measured in 9 regions of interest (ROIs): the right and left sides of the medial prefrontal cortex, dorsolateral prefrontal cortex, putamen and caudate nucleus, and the single “whole brain”.

The dataset was originally published in DiVA and moved to SND in 2024.

Data contains personal data

Language

English

Method and outcome

Time period(s) investigated

2016 – 2017

Data format / data structure

Numeric

Data collection

Geographic coverage

Administrative information

Contributor(s)

Ulf Olsson - Swedish University of Agricultural Sciences, Unit of Applied Statistics and Mathematics

Anders Wall - Uppsala University, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.

Identifiers

URN: urn:nbn:se:uu:diva-486901

Topic and keywords

Research area

Obstetrics, gynaecology and reproductive medicine (Standard för svensk indelning av forskningsämnen 2011)

Keywords

5-hydroxytryptophan, Image interpretation, computer-assisted, Menstrual cycle, Positron-emission tomography, Premenstrual dysphoric disorder, Gynecology, Reproductive health, Premenstrual syndrome

Publications

Eriksson O, Wall A, Olsson U, Marteinsdottir I, Holstad M, Ågren H, et al. (2016) Women with Premenstrual Dysphoria Lack the Seemingly Normal Premenstrual Right-Sided Relative Dominance of 5-HTP-Derived Serotonergic Activity in the Dorsolateral Prefrontal Cortices - A Possible Cause of Disabling Mood Symptoms. PLoS ONE 11(9): e0159538. doi:10.1371/journal.pone.0159538
URN: urn:nbn:se:uu:diva-311612
DOI: https://doi.org/10.1371/journal.pone.0159538

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Published: 2024-06-24