Data on brain serotonergic activity in Premenstrual Dysphoria

SND-ID: 2024-382. Version: 1. DOI:


Creator/Principal investigator(s)

Olle Eriksson - Uppsala University, Department of Women's and Children's Health, Obstetrics and Gynaecology. orcid

Research principal

Uppsala University rorId


Dataset investigating potential quantitative and qualitative differences in brain serotonergic activity between women with Premenstrual Dysphoria (PMD) and asymptomatic controls.

Positron-emission tomography with the immediate precursor of serotonin, 5-hydroxytryptophan (5-HTP), radiolabelled by 11C in the beta-3 position, was performed in the follicular and luteal phases for 12 women with PMD and 8 control women. Brain radioactivity–a proxym for serotonin precursor uptake and synthesis–was measured in 9 regions of interest (ROIs): the right and left sides of the medial prefrontal cortex, dorsolateral prefrontal cortex, putamen and caudate nucleus, and the single “whole brain”.

The dataset was originally published in DiVA and moved to SND in 2024.

Data contains personal data



Method and outcome

Time period(s) investigated

2016 – 2017

Data format / data structure

Data collection
Geographic coverage
Administrative information


Ulf Olsson - Swedish University of Agricultural Sciences, Unit of Applied Statistics and Mathematics

Anders Wall - Uppsala University, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET. orcid



Eriksson O, Wall A, Olsson U, Marteinsdottir I, Holstad M, Ågren H, et al. (2016) Women with Premenstrual Dysphoria Lack the Seemingly Normal Premenstrual Right-Sided Relative Dominance of 5-HTP-Derived Serotonergic Activity in the Dorsolateral Prefrontal Cortices - A Possible Cause of Disabling Mood Symptoms. PLoS ONE 11(9): e0159538. doi:10.1371/journal.pone.0159538
URN: urn:nbn:se:uu:diva-311612

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Published: 2024-06-24