Data on brain serotonergic activity in Premenstrual Dysphoria
SND-ID: 2024-382. Version: 1. DOI: https://doi.org/10.57804/8e1r-pj05
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Creator/Principal investigator(s)
Olle Eriksson - Uppsala University, Department of Women's and Children's Health, Obstetrics and Gynaecology.
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Description
Positron-emission tomography with the immediate precursor of serotonin, 5-hydroxytryptophan (5-HTP), radiolabelled by 11C in the beta-3 position, was performed in the follicular and luteal phases for 12 women with PMD and 8 control women. Brain radioactivity–a proxym for serotonin precursor uptake and synthesis–was measured in 9 regions of interest (ROIs): the right and left sides of the medial prefrontal cortex, dorsolateral prefrontal cortex, putamen and caudate nucleus, and the single “whole brain”.
The dataset was originally published in DiVA and moved to SND in 2024.
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No
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Time period(s) investigated
2016 – 2017
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Research area
Obstetrics, gynaecology and reproductive medicine (Standard för svensk indelning av forskningsämnen 2011)
Eriksson O, Wall A, Olsson U, Marteinsdottir I, Holstad M, Ågren H, et al. (2016) Women with Premenstrual Dysphoria Lack the Seemingly Normal Premenstrual Right-Sided Relative Dominance of 5-HTP-Derived Serotonergic Activity in the Dorsolateral Prefrontal Cortices - A Possible Cause of Disabling Mood Symptoms. PLoS ONE 11(9): e0159538. doi:10.1371/journal.pone.0159538
URN:
urn:nbn:se:uu:diva-311612
DOI:
https://doi.org/10.1371/journal.pone.0159538