Supplementary Table for "The Plasma Metabolomic Profile is Differently Associated with Liver Fat, Visceral Adipose Tissue, and Pancreatic Fat"
SND-ID: 2024-294. Version: 1. DOI: https://doi.org/10.57804/9kxk-ra38
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Creator/Principal investigator(s)
Lars Lind
- Uppsala University
Research principal
Description
Data (tables) associated with the manuscript "The Plasma Metabolomic Profile is Differently Associated with Liver Fat, Visceral Adipose Tissue, and Pancreatic Fat" by Lind et al. 2021.
Context: Metabolic differences between ectopic fat depots may provide novel insights to obesity-related diseases.
Objective: To investigate the plasma metabolomic profiles in relation to visceral adipose tissue (VAT) volume and liver and pancreas fat percentages.
Design: Cross-sectional.
Setting: Multicenter at academic research laboratories.
Context: Metabolic differences between ectopic fat depots may provide novel insights to obesity-related diseases.
Objective: To investigate the plasma metabolomic profiles in relation to visceral adipose tissue (VAT) volume and liver and pancreas fat percentages.
Design: Cross-sectional.
Setting: Multicenter at academic research laboratories.
Patients: Magnetic resonance imaging (MRI) was used to assess VAT volume, the percentage of fat in the liver and pancreas (proton density fat fraction [PDFF]) at baseline in 310 individuals with a body mass index ≥ 25 kg/m2 and with serum triglycerides ≥ 1.7 mmol/l and/or type 2 diabetes screened for inclusion in the 2 effect of omega-3 carboxylic acid on liver fat content studies.
Intervention: None.
Main outcome measure: Metabolomic profiling with mass spectroscopy enabled the determination of 1063 plasma metabolites.
The dataset was originally published in DiVA and moved to SND in 2024. Show less..
Data contains personal data
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Contributor(s)
Samira Salihovic
- Örebro University, School of Medical Sciences
Ulf Risérus
- Uppsala University, Klinisk nutrition och metabolism
Joel Kullberg
- Uppsala University, Radiology
Lars Johansson - Antaros Medical AB, Gothenburg, Sweden
Håkan Ahlström - Uppsala University, Radiology
... Show more..
Samira Salihovic
- Örebro University, School of Medical Sciences
Ulf Risérus
- Uppsala University, Klinisk nutrition och metabolism
Joel Kullberg
- Uppsala University, Radiology
Lars Johansson - Antaros Medical AB, Gothenburg, Sweden
Håkan Ahlström - Uppsala University, Radiology
Jan Eriksson
- Uppsala University, Institutionen för medicinska vetenskaper
Jan Oscarsson - BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
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Research area
Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)
Keywords
Ectopic fat, Mri, Liver fat, Pancreatic fat, Metabolomics, Obesity
Lind L, Salihovic S, Risérus U, Kullberg J, Johansson L, Ahlström H, Eriksson JW, Oscarsson J. The Plasma Metabolomic Profile is Differently Associated with Liver Fat, Visceral Adipose Tissue, and Pancreatic Fat. J Clin Endocrinol Metab. 2021 Jan 1;106(1):e118-e129. doi: 10.1210/clinem/dgaa693. PMID: 33123723; PMCID: PMC7765636.
DOI:
https://doi.org/10.1210/clinem/dgaa693
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