Neurofilament Light as a biomarker for neurotoxicity after isolated limb perfusion - a prospective feasibility trial

SND-ID: 2023-251. Version: 1. DOI: https://doi.org/10.5878/ykq2-1r07

Citation

Creator/Principal investigator(s)

Anna Corderfeldt Keiller - University of Gothenburg, Institute of Clinical Sciences orcid

Research principal

University of Gothenburg - Institute of Clinical Sciences, Department of Surgery rorId

Description

Explorative feasibility trial where patients scheduled for isolated limb perfusion were included. Blood samples were taken and a physiotherapist examined the patients pre- and post surgery for evaluation of nerve damage post isolated limb perfusion.

Dataset contents:
Measurements, blood samples, health status.

Data contains personal data

Yes

Sensitive personal data

Yes

Type of personal data

Health status

Code key exists

Yes

Language

Method and outcome

Population

Patients scheduled for isolated limb perfusion because of cancer tumours

Time Method

Study design

Experimental study

Description of study design

Explorative feasibility trial where patients scheduled for isolated limb perfusion were included. Blood samples were taken and a physiotherapist examined the patients pre- and post surgery for evaluation of nerve damage post isolated limb perfusion.

Sampling procedure

Total universe/Complete enumeration
Consecutive patients scheduled for isolated limb perfusion (ILP) that fulfilled inclusion criteria

Time period(s) investigated

2019-04-12 – 2020-09-25

Biobank is connected to the study

The study has collected samples/material which are stored in a scientific collection or biobank

Scientific collection or biobank name: Biobank Sverige ID: PS-0499-5-001

Type(s) of sample: Blood samples

Variables

192

Number of individuals/objects

18

Data format / data structure

Data collection
  • Mode of collection: Measurements and tests
  • Description of the mode of collection: Hemodymamic patient monitor, blood samples and test results from physiotherapist
  • Time period(s) for data collection: 2019-04-11 – 2020-10-23
  • Data collector: University of Gothenburg
  • Sample: Blood gas
    Blood sampling from heart-lung machine and venous samples on 30 day follow up
  • Sample: Blood samples
    Neuronal markers
  • Sample size: 18
  • Non response size: 1
  • Source of the data: Biological samples
Geographic coverage

Geographic spread

Geographic location: Sweden

Geographic description: Patients from all over Sweden

Administrative information

Responsible department/unit

Institute of Clinical Sciences, Department of Surgery

Contributor(s)

Roger Olofsson Bagge - University of Gothenburg, Institute of Clinical Sciences orcid

Ethics Review

Swedish Ethical Review Authority - Ref. 2019-01046

Publications

Corderfeldt Keiller A, Axelsson M, Bragadottir G, Blennow K, Zetterberg H, Olofsson Bagge R. A prospective feasibility trial exploring novel biomarkers for neurotoxicity after isolated limb perfusion. Perfusion. 2023;0(0). doi:10.1177/02676591231213506
DOI: https://doi.org/10.1177/02676591231213506

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Versions

Version 1. 2024-09-09

Version 1: 2024-09-09

DOI: https://doi.org/10.5878/ykq2-1r07

Contact for questions about the data

Anna Corderfeldt Keiller

anna.corderfeldt@gu.se

Published: 2024-09-09