Neurofilament Light as a biomarker for neurotoxicity after isolated limb perfusion - a prospective feasibility trial

SND-ID: 2023-251. Version: 1. DOI: https://doi.org/10.5878/ykq2-1r07

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Associated documentation

Data PEK 4 all data codebook.docx (32.84 KB)

Data PEK 4 all data codebook.pdf (184.62 KB)

Data PEK 4 longitudinell codebook.docx (16.89 KB)

Data PEK 4 longitudinell codebook.pdf (56.76 KB)

PEK3 Alla analyser codebook.docx (109.04 KB)

PEK3 Alla analyser codebook.pdf (293.24 KB)

PEK3 longitudinella matningar codebook.docx (66.44 KB)

PEK3 longitudinella matningar codebook.pdf (202.89 KB)

Variabelförklaring.docx (20.24 KB)

Citation

Creator/Principal investigator(s)

Anna Corderfeldt Keiller - University of Gothenburg, Institute of Clinical Sciences

Research principal

University of Gothenburg - Institute of Clinical Sciences, Department of Surgery

Description

Explorative feasibility trial where patients scheduled for isolated limb perfusion were included. Blood samples were taken and a physiotherapist examined the patients pre- and post surgery for evaluation of nerve damage post isolated limb perfusion.

Dataset contents:
Measurements, blood samples, health status.

Data contains personal data

Yes

Sensitive personal data

Yes

Type of personal data

Health status

Code key exists

Yes

Language

Swedish

Method and outcome

Unit of analysis

Time unit

Event/Process/Activity

Cells

Organ

Individual/Patient

Population

Patients scheduled for isolated limb perfusion because of cancer tumours

Time Method

Longitudinal

Study design

Experimental study

Description of study design

Sampling procedure

Total universe/Complete enumeration

Consecutive patients scheduled for isolated limb perfusion (ILP) that fulfilled inclusion criteria

Time period(s) investigated

2019-04-12 – 2020-09-25

Biobank is connected to the study

The study has collected samples/material which are stored in a scientific collection or biobank

Scientific collection or biobank name: Biobank Sverige ID: PS-0499-5-001

Type(s) of sample: Blood samples

Variables

192

Number of individuals/objects

Data format / data structure

Numeric

Text

Data collection

Mode of collection: Measurements and tests
Description of the mode of collection: Hemodymamic patient monitor, blood samples and test results from physiotherapist
Time period(s) for data collection: 2019-04-11 – 2020-10-23
Data collector: University of Gothenburg
Sample: Blood gas
Blood sampling from heart-lung machine and venous samples on 30 day follow up
Sample: Blood samples
Neuronal markers
Sample size: 18
Non response size: 1
Source of the data: Biological samples

Geographic coverage

Geographic spread

Geographic location: Sweden

Geographic description: Patients from all over Sweden

Administrative information

Responsible department/unit

Institute of Clinical Sciences, Department of Surgery

Contributor(s)

Roger Olofsson Bagge - University of Gothenburg, Institute of Clinical Sciences

Ethics Review

Swedish Ethical Review Authority - Ref. 2019-01046

Topic and keywords

Research area

Physiology (Standard för svensk indelning av forskningsämnen 2011)

Cancer and oncology (Standard för svensk indelning av forskningsämnen 2011)

Specific diseases, disorders and medical conditions (CESSDA Topic Classification)

Keywords

Neoplasms, Biomarkers, Extremities, Nervous system, Chemotherapy, cancer, regional perfusion, Skin neoplasms, Neurofilament proteins, Neurotoxicity syndromes, Sarcoma, myeloid, Myeloid sarcoma, Kontrollundersökning efter behandling för malignt melanom i huden

Publications

Corderfeldt Keiller A, Axelsson M, Bragadottir G, Blennow K, Zetterberg H, Olofsson Bagge R. A prospective feasibility trial exploring novel biomarkers for neurotoxicity after isolated limb perfusion. Perfusion. 2023;0(0). doi:10.1177/02676591231213506
DOI: https://doi.org/10.1177/02676591231213506

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