TARGET-seq genotyped single-cell RNA sequencing of hematopoietic stem cells and megakaryocyte-erythroid progenitor cells from a dual SF3B1-mutant MDS-RS patient and 3 healthy donors
SND-ID: 2023-223. Version: 1. DOI: https://doi.org/10.48723/d7s9-6336
Associated documentation
Citation
Creator/Principal investigator(s)
Pedro Luis Moura - Karolinska Institutet, Department of Medicine, Huddinge / Center for Hematology and Regenerative Medicine (HERM)
Eva Hellström-Lindberg - Karolinska Institutet, Department of Medicine, Huddinge / Center for Hematology and Regenerative Medicine (HERM)
Research principal
Karolinska Institutet - Department of Medicine, Huddinge / Center for Hematology and Regenerative Medicine (HERM)
Description
The dataset is approximately 187 GB and includes the file types: zip, xlsx, bam, bam.bai, rds.
Data contains personal data
Yes
Sensitive personal data
Yes
Type of personal data
Genetic and biological data of patients
Code key exists
Yes
Language
Unit of analysis
Population
Patients with Myelodysplastic neoplasms with ring sideroblasts (MDS-RS)
Time Method
Study design
Preclinical study
Sampling procedure
Non-probability: Availability
Mixed probability and non-probability
Biobank is connected to the study
This study has used existing samples from a scientific collection or biobank
Scientific collection or biobank name: Karolinska Institutet MDS biobank
Type(s) of sample: Bone marrow cells
Responsible department/unit
Department of Medicine, Huddinge / Center for Hematology and Regenerative Medicine (HERM)
Contributor(s)
Affaf Aliouat - University of Oxford
Sten Eirik Jacobsen - Karolinska Institutet
Petter Woll - Karolinska Institutet
Ethics Review
Stockholm - Ref. 2017/1090-31/4
Research area
Natural sciences (Standard för svensk indelning av forskningsämnen 2011)
Biological sciences (Standard för svensk indelning av forskningsämnen 2011)
Cell biology (Standard för svensk indelning av forskningsämnen 2011)
Genetics (Standard för svensk indelning av forskningsämnen 2011)
Bioinformatics and systems biology (Standard för svensk indelning av forskningsämnen 2011)
Hematology (Standard för svensk indelning av forskningsämnen 2011)
Keywords
Pedro Luis Moura, Yasuhito Nannya, Affaf Aliouat, Isabel Juliana Hofman, Teresa Mortera Blanco, Tetsuichi Yoshizato, Ryunosuke Saiki, Masahiro M Nakagawa, Maria Creignou, Ann-Charlotte Björklund, Gunilla Walldin, Indira Barbosa, Monika Jansson, Francesca Grasso, Edda M Elvarsdottir, Petter S Woll, Sten Eirik W Jacobsen, Seishi Ogawa, Eva Hellström-Lindberg, Competition of dual SF3B1mt clones in MDS-RS is associated with distinct RNA mis-splicing in hematopoietic stem cells,
Blood Neoplasia, 2024,100011, ISSN 2950-3280,
https://doi.org/10.1016/j.bneo.2024.100011.
DOI:
https://doi.org/10.1016/j.bneo.2024.100011
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