A landscape of X-inactivation during human T-cell development in the thymus
SND-ID: 2022-112-1. Version: 2. DOI: https://doi.org/10.5878/ayae-p143
Citation
Creator/Principal investigator(s)
Olov Ekwall
- University of Gothenburg, Institute of Clinical Sciences, Department of Pediatrics
Research principal
University of Gothenburg
- Institute of Clinical Sciences
Description
The dataset contains data from the manuscript "A landscape of X-inactivation during human T-cell development in the thymus" by Gylemo et al, and consists of results from RNA sequencing (fastq.gz), analysis of DNA methylation (Grn.idat), Smart-seq2 single-cell RNA sequencing (fastq.gz) and whole exome DNA sequencing (fastq.gz) of six developmental stages of thymocytes from nine individuals.
The data is described on individual and cell-type level in the tab-separated metadata files (.tsv).
MD5 checksums for each file are included.
Data contains personal data
Yes
Sensitive personal data
Yes
Type of personal data
Human data. The data is pseudonymized and contains ID-numbers that can be coupled to individuals through a code key.
Code key exists
Yes
Language
Unit of analysis
Population
Isolated thymocytes from nine persons were studied, four boys and five girls, all under 3 years that underwent cardiac surgery for correction of congenital heart defects.
Study design
Experimental study
Sampling procedure
Biobank is connected to the study
The study has collected samples/material which are stored in a scientific collection or biobank
Scientific collection or biobank name: Biobank Väst 890
Type(s) of sample: Isolerade thymocyter
This study has used existing samples from a scientific collection or biobank
Number of individuals/objects
9
Geographic spread
Geographic location: Sweden
Responsible department/unit
Institute of Clinical Sciences
Other research principals
Contributor(s)
Colm E Nestor
- Linköping University, Department of Biomedical and Clinical Sciences, Division of Children's and Women's Health
Funding 1
-
Funding agency:
Swedish Research Council
- Funding agency's reference number: 2018-02752
- Project name on the application: Clinical and experimental studies of tolerance mechanisms in the thymus aiming at the development of therapeutic targeting of the thymus in the treatment of autoimmune diseases
Funding 2
-
Funding agency:
The ALF agreement: The Swedish state under the ALF agreement between the Swedish government and the county councils
- Funding agency's reference number: ALFGBG-965795
- Project name on the application: Kliniska och experimentella studier av toleransmekanismer i thymus
Ethics Review
Gothenburg - Ref. 217-12
Project title: Studies of central tolerance induction in human thymus
Research area
Immunology in the medical area (Standard för svensk indelning av forskningsämnen 2011)
Björn Gylemo, Maike Bensberg, Viktoria Hennings, Christina Lundqvist, , Alessandro Camponeschi, Dora Goldman, Aida Selimović, Antonio Lentini, Olov Ekwall, Colm E. Nestor (2024). A landscape of X-inactivation during human T-cell development [manuscript, resubmitted after revision].
If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.
