Rotational Thromboelastometry predicts care level in COVID-19
SND-ID: 2020-43-1. Version: 1. DOI: https://doi.org/10.5878/wh80-0w17
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Creator/Principal investigator(s)
Lou Almskog - Karolinska Institutet, Department of Molecular Medicine and Surgery
Anna Ågren - Karolinska University Hospital / Danderyd Hospital, Coagulation Unit, Division of Hematology / Department of Clinical Sciences
Research principal
Karolinska Institutet
- Karolinska Institutet
Description
The objective of the study was to test whether Rotational Thromboelastometry (ROTEM) indicate hypercoagulopathy at hospitalization of COVID-19 patients, and whether patients with severe disease have a more pronounced hypercoagulopathy compared with less severely ill patients.
The study was designed as a prospective observational study where COVID-19 positive patients over 18 years admitted to Capio St Göran’s Hospital in Stockholm, Sweden, were eligible for inclusion. Patients were divided into two groups depending on care level: 1) regular wards (40 patients) or 2) wards with specialized ventilation support (20 patients). ROTEM and other coagulation tests (see table for a list and explanation of variables) was taken after admission and the data were compared with ROTEM in healthy controls.
Conclusion
ROTEM variables (EXTEM-MCF, FIBTEM-MCF, EXTEM-CT, EXTEM-CFT) were significantly different in COVID-19 patients early after admission compared with healthy controls. This pattern was more pronounced in patients with increased disease severity, suggesting that ROTEM-analysis could be a potential
The study was designed as a prospective observational study where COVID-19 positive patients over 18 years admitted to Capio St Göran’s Hospital in Stockholm, Sweden, were eligible for inclusion. Patients were divided into two groups depending on care level: 1) regular wards (40 patients) or 2) wards with specialized ventilation support (20 patients). ROTEM and other coagulation tests (see table for a list and explanation of variables) was taken after admission and the data were compared with ROTEM in healthy controls.
Conclusion
ROTEM variables (EXTEM-MCF, FIBTEM-MCF, EXTEM-CT, EXTEM-CFT) were significantly different in COVID-19 patients early after admission compared with healthy controls. This pattern was more pronounced in patients with increased disease severity, suggesting that ROTEM-analysis could be a potentially useful predictor of thromboembolic complications and mortality in these patients.
For details, see publication at: https://doi.org/10.1007/s11239-020-02312-3 Show less..
Data contains personal data
No
Language
Population
Patients treated for COVID-19
Study design
Observational study
Time period(s) investigated
2020-05-08 – 2020-05-31
Variables
12
Number of individuals/objects
60
Data format / data structure
Responsible department/unit
Karolinska Institutet
Contributor(s)
Jonas Svensson - Karolinska Institutet
Ethics Review
Swedish Ethical Review Authority - Ref. D-nr 2020-01875
Research area
Anesthesiology and intensive care (Standard för svensk indelning av forskningsämnen 2011)
Hematology (Standard för svensk indelning av forskningsämnen 2011)
Keywords
Rotational Thromboelastometry predicts care level in Covid-19
Lou Almskog, Agneta Wikman, Jonas Svensson, Michael Wanecek, Matteo Bottai, Jan van der Linden, Anna Agren
medRxiv 2020.06.11.20128710; doi: https://doi.org/10.1101/2020.06.11.20128710
DOI:
https://doi.org/10.1101/2020.06.11.20128710
Almskog, L., Wikman, A., Svensson, J., Wanecek, M., Bottai, M., van der Linden, J., & Agren, A. (2021). Rotational thromboelastometry results are associated with care level in COVID-19. In Journal of thrombosis and thrombolysis (Vol. 5251, Issue 12, pp. 437–445). https://doi.org/10.1007/s11239-020-02312-3
DOI:
https://doi.org/10.1007/s11239-020-02312-3
SwePub:
oai:prod.swepub.kib.ki.se:144915141
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