Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin

SND-ID: snd1058-1. Version: 1.0. DOI:


Creator/Principal investigator(s)

Gunnar Johanson - Karolinska Institutet, Institute of Environmental Medicine

Research principal

Karolinska Institutet rorId


We tested a larger number of organic solvents with the same experimental set up, using skin from new-born piglets and static diffusion cells. Thirty-six common organic solvents were studied neat (and 31 of them also in water dilution): acetone, acetonitrile, n-butanol 2-butanone 2-butoxyethanol, 1-butoxy-2-propanol, n-butyl acetate, butyl acrylate, cyclohexane, cyclohexanone, 1,2-dichloroethane, dichloromethane, ethanol, 2-ethoxyethanol, ethyl acetate, ethyl acrylate, ethylbenzene, furfuryl alcohol, n-hexane, 2-hexanone, 2-isopropoxyethanol, methanol, 1-methoxy-2-propanol, methyl acrylate, 3-methyl-1-butanol, methyl tertiary butyl ether, 4-metyl-2-pentanol, methyl methacrylate, 2-propanol, 2-propen-1-ol, 2-propoxyethanol, 1-propoxy-2-propanol, styrene, trichloromethane, toluene and m-xylene.

Experiments for one substance(dilution) are reported in one worksheet. We report peak areas for the gas chromatographic analyses and the calculated skin permeation parameters for each experiment.


Method and outcome

Time period(s) investigated

2005 – 2012

Data format / data structure

Data collection
  • Mode of collection: Experiment
  • Time period(s) for data collection: 2005 – 2012
  • Source of the data: Biological samples
Geographic coverage
Administrative information
Topic and keywords

Research area

Occupational health and environmental health (Standard för svensk indelning av forskningsämnen 2011)

Occupational health (CESSDA Topic Classification)

Published: 2018-09-28
Last updated: 2018-09-28