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Uppsala Longitudinal Study of Adult Men (ULSAM)

SND-ID: ext0051-1.

Is part of collection at SND: Swedish Cohort Consortium (Cohorts.se), Swedish Diet Cohort Consortium (SDCC)

Access to data via

Citation

Creator/Principal investigator(s)

Peter Nordström - Uppsala University, Department of Public Health and Caring Sciences orcid

Research principal

Uppsala University - Department of Public Health and Caring Sciences rorId

Description

Uppsala Longitudinal Study of Adult Men (ULSAM) is a unique, ongoing, longitudinal, epidemiologic study based on all available men, born between 1920 and 1924 and living in Uppsala County, Sweden. The aim of Uppsala Study of Adult Men (ULSAM) is to investigate the risk factors for common diseases, including biochemical markers, variations in the genome and life style factors.

ULSAM started as a health investigation, focused at identifying metabolic risk factors for cardiovascular disease, to which all 50 year-old men living in Uppsala in 1970 were invited. Of these, 82% (2322 men) participated in the investigation. The men were thereafter investigated again at ages 60, 70, 77, 82, 88 and 93 years. In the 93 years investigation, which was completed in spring 2015, even spouses to the men from original cohort have participated.

ULSAM is focused on several areas with a wide range of phenotypes collected. These areas include glucose and insulin metabolism, blood pressure, anthropometry, lipids and fatty acid composition, diet, cognitive function, socio-economic factors, heredity, medical histor

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Uppsala Longitudinal Study of Adult Men (ULSAM) is a unique, ongoing, longitudinal, epidemiologic study based on all available men, born between 1920 and 1924 and living in Uppsala County, Sweden. The aim of Uppsala Study of Adult Men (ULSAM) is to investigate the risk factors for common diseases, including biochemical markers, variations in the genome and life style factors.

ULSAM started as a health investigation, focused at identifying metabolic risk factors for cardiovascular disease, to which all 50 year-old men living in Uppsala in 1970 were invited. Of these, 82% (2322 men) participated in the investigation. The men were thereafter investigated again at ages 60, 70, 77, 82, 88 and 93 years. In the 93 years investigation, which was completed in spring 2015, even spouses to the men from original cohort have participated.

ULSAM is focused on several areas with a wide range of phenotypes collected. These areas include glucose and insulin metabolism, blood pressure, anthropometry, lipids and fatty acid composition, diet, cognitive function, socio-economic factors, heredity, medical history, and common risk factors for cardiovascular disease. In the latest investigation we are particularly focusing on the factors leading to healthy ageing.

The longitudinal design of the study contributes to the collection of the same (or similar) phenotypes at several points in time. The loss of follow up end points is very low due to yearly matching with official cause-of-death and hospital discharge registries. Very important research area in ULSAM is analysis of genetic factors affecting common diseases. We have DNA samples available from more than 1200 men. Using modern genotyping technologies, these samples have been analyzed for over 2.5 million SNPs. We are also planning to perform whole genome sequencing for all individuals with DNA samples available.

Large number of researchers are using ULSAM data in their studies. ULSAM is involved in several international collaborations as well. Over 300 articles have been published from ULSAM initiation in 1970 and at least 30 doctoral theses explored data collected in our study. Show less..

Data contains personal data

Yes

Sensitive personal data

Yes

Type of personal data

The data are pseudonymized and contain indirect identifiers as well as different health, clinical and genetic data

Code key exists

Yes

Language

Method and outcome

Unit of analysis

Population

Men born 1920-1924 in Uppsala county

Time Method

Study design

Observational study

Sampling procedure

Time period(s) investigated

1970 – 1973

1980 – 1984

1991 – 1995

1997 – 2001

2003 – 2005

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1970 – 1973

1980 – 1984

1991 – 1995

1997 – 2001

2003 – 2005

2008 – 2009

2014 – 2015

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Biobank is connected to the study

This study has used existing samples from a scientific collection or biobank

Response rate/participation rate

Age 50: 2322 individuals
Age 60: 1860 individuals
Age 70: 1221 individuals
Age 77: 839 individuals
Age 82: 530 individuals
Age 88: 354 individuals
Age 93: 168 individuals

Data format / data structure

Data collection

Data collection 1

  • Description of the mode of collection:
    Focus group: face-to-face
    Psychological measurements and tests
    Self-administered questionnaire: paper
    Participant laboratory observation
    Laboratory observation
    Measurements and tests
    Face-to-face interview
    Telephone interview
  • Time period(s) for data collection: 1970 – 1973
  • Number of responses: 2322
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples, Registers/Records/Accounts

Data collection 2

  • Description of the mode of collection:
    Focus group: face-to-face
    Psychological measurements and tests
    Self-administered questionnaire: paper
    Participant laboratory observation
    Laboratory observation
    Measurements and tests
    Face-to-face interview
    Telephone interview
  • Time period(s) for data collection: 1980 – 1984
  • Number of responses: 1860
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples, Registers/Records/Accounts

Data collection 3

  • Description of the mode of collection:
    Focus group: face-to-face
    Psychological measurements and tests
    Self-administered questionnaire: paper
    Participant laboratory observation
    Laboratory observation
    Measurements and tests
    Face-to-face interview
    Telephone interview
  • Time period(s) for data collection: 1991 – 1995
  • Number of responses: 1221
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples, Registers/Records/Accounts
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Data collection 1

  • Description of the mode of collection:
    Focus group: face-to-face
    Psychological measurements and tests
    Self-administered questionnaire: paper
    Participant laboratory observation
    Laboratory observation
    Measurements and tests
    Face-to-face interview
    Telephone interview
  • Time period(s) for data collection: 1970 – 1973
  • Number of responses: 2322
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples, Registers/Records/Accounts

Data collection 2

  • Description of the mode of collection:
    Focus group: face-to-face
    Psychological measurements and tests
    Self-administered questionnaire: paper
    Participant laboratory observation
    Laboratory observation
    Measurements and tests
    Face-to-face interview
    Telephone interview
  • Time period(s) for data collection: 1980 – 1984
  • Number of responses: 1860
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples, Registers/Records/Accounts

Data collection 3

  • Description of the mode of collection:
    Focus group: face-to-face
    Psychological measurements and tests
    Self-administered questionnaire: paper
    Participant laboratory observation
    Laboratory observation
    Measurements and tests
    Face-to-face interview
    Telephone interview
  • Time period(s) for data collection: 1991 – 1995
  • Number of responses: 1221
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples, Registers/Records/Accounts

Data collection 4

  • Description of the mode of collection:
    Focus group: face-to-face
    Psychological measurements and tests
    Self-administered questionnaire: paper
    Participant laboratory observation
    Laboratory observation
    Measurements and tests
    Face-to-face interview
    Telephone interview
  • Time period(s) for data collection: 1997 – 2001
  • Number of responses: 839
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples, Registers/Records/Accounts

Data collection 5

  • Description of the mode of collection:
    Focus group: face-to-face
    Psychological measurements and tests
    Self-administered questionnaire: paper
    Participant laboratory observation
    Laboratory observation
    Measurements and tests
    Face-to-face interview
    Telephone interview
  • Time period(s) for data collection: 2003 – 2005
  • Number of responses: 530
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples, Registers/Records/Accounts

Data collection 6

  • Description of the mode of collection:
    Focus group: face-to-face
    Psychological measurements and tests
    Self-administered questionnaire: paper
    Participant laboratory observation
    Laboratory observation
    Measurements and tests
    Face-to-face interview
    Telephone interview
  • Time period(s) for data collection: 2008 – 2009
  • Number of responses: 354
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples, Registers/Records/Accounts

Data collection 7

  • Description of the mode of collection:
    Focus group: face-to-face
    Psychological measurements and tests
    Self-administered questionnaire: paper
    Participant laboratory observation
    Laboratory observation
    Measurements and tests
    Face-to-face interview
    Telephone interview
  • Time period(s) for data collection: 2014 – 2015
  • Number of responses: 168
  • Source of the data: Registers/Records/Accounts: Medical/Clinical, Population group, Biological samples, Registers/Records/Accounts
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Geographic coverage

Geographic spread

Geographic location: Sweden

Geographic description: Uppsala county

Lowest geographic unit

County (NUTS3)

Highest geographic unit

County (NUTS3)

Administrative information

Responsible department/unit

Department of Public Health and Caring Sciences

Ethics Review

Uppsala - Ref. Dnr 251/90

ULSAM-70: Dnr 251/90, godkänt 1991-08-21

Uppsala - Ref. Dnr 2013/350

ULSAM-93: Dnr 2013/350, godkänt 2013-10-23

Topic and keywords

Research area

Medical and health sciences (Standard för svensk indelning av forskningsämnen 2011)

Public health, global health, social medicine and epidemiology (Standard för svensk indelning av forskningsämnen 2011)

Health (CESSDA Topic Classification)

Keywords

Ageing, Blood pressure, Cohort studies, Health surveys, Dementia, Dyspnea, Residence characteristics, Life style, Medicine, Nursing care, Movement, Exercise, Muscular diseases, Osteoporosis, Urinary incontinence, Mortality, Neoplasms, Diet, Alcohol drinking, Chest pain, Diabetes mellitus, Leisure activities, Genetics, Cardiovascular diseases, Dietary supplements, Body weight, Angina pectoris, Lung diseases, Oral health, Smoking, Tobacco, smokeless, Dairy products, Family relations, Feeding behavior, Focus groups, Foods, specialized, Sedentary behavior, Lifestyle factors, Disabilities, Swedish cohort consortium (scc), Swedish diet cohort consortium (sdcc), Sdcc, Cohorts.se

Publications
Link to publication list:

If you have published anything based on these data, please notify us with a reference to your publication(s). If you are responsible for the catalogue entry, you can update the metadata/data description in DORIS.

Contacts for questions about the data